多耐药铜绿假单胞菌院内感染影响因素分析  

Influencing Factors of Hospital Infections Caused by Multi-resistant Pseudomonas Aeruginosa

作　　者：陈保锦[1] 

机构地区：[1]兰州大学第一医院检验科,兰州730000

出　　处：《解放军预防医学杂志》2017年第6期642-643,646,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：甘肃省自然科学研究基金项目(No.1010RJZA120)

摘　　要：目的探讨影响住院患者多药耐药铜绿假单胞菌(MDRP)院内感染危险因素分析。方法选取我院2013年11月-2014年9月因铜绿假单胞菌引起的院内感染患者112例,根据患者MDRP检测结果,将112例患者分为MDRP组(43例)与非MDRP组(69例),对两组进行对照研究,采用多因素Cox分析影响MDRP院内感染的危险因素。结果患者年龄、ICU/RCU、APACHEⅡ评分、COPD/支扩、混合感染、机械通气、亚胺培南、美罗培南为影响MDRP院内感染的单因素(P<0.01);经多因素Cox分析结果得出:APACHEⅡ≥16分、机械通气、亚胺培南、美罗培南为影响MDRP院内感染的危险因素(P<0.01)。结论 APACHEⅡ≥16分、机械通气及使用亚胺培南或美罗培南为影响MDRP院内感染的危险因素。Objective To investigate the influencing factors of hospital infections caused by multi-resistant pseudomonas aeruginosa （MDRP）. Methods A total of 112 patients with hospital infections caused by MDRP in our hospital between November 2013 and September 2014 were selected and divided into the MDRP group （43 cases） and non MDRP group （69 cases） accord- ing to MDRP results. Multiariable Cox analysis was used to analyze the risk factors of these cases of infections. Results Age, ICU/ RCU, APACHE Ⅱ score, COPD/ bronchiectasis, mixed infections, mechanical ventilation, imipenem, and meropenem were single factors that influenced hospital infections associated with MDRP （P〈0.05）. Muhiariable Cox analysis showed that APACHEⅡ ≥ 16, mechanical ventilation ,imipenem and meropenem were risk factors that influenced hospital infections associated with MDRP （P〈0. 01 ）. Conclusion APACHEⅡ ≥ 16, mechanical ventilation, and the use of imipenem and meropenem are risk factors that affect hospital infections caused by MDRP.

关 键 词：多药耐药铜绿假单胞菌 院内感染 危险因素 

分 类 号：R37[医药卫生—病原生物学]