2型糖尿病肾病高危因素、发病机制及营养治疗的研究进展  

Research Progress in High Risk Factors,Pathogenesy and Nutrition Therapy for Type 2 Diabetic Nephropathy

作　　者：刘洁[1] 滑丽美[2] 史永红[3] 

机构地区：[1]白求恩国际和平医院信息科,石家庄050082 [2]白求恩国际和平医院营养科 [3]白求恩国际和平医院肾脏病科

出　　处：《解放军预防医学杂志》2017年第6期690-693,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：河北省2015年度医学科学研究重点课题(No.20150387)

摘　　要：糖尿病肾病为糖尿病最常见的微血管并发症,发病机制不明。文章综述了包括基因与遗传易感性、氧化应激、脂肪因子及血液流变学异常等可能发病机制,指出病程、体质指数、血脂与糖化血红蛋白是糖尿病肾病的独立危险因素,遗传易感性、炎症、凝血功能异常、高血压、高血糖、高血脂等均起到了一定作用。临床延缓疾病发展的重要措施即是医学营养治疗,可根据患者病情、治疗目标,制定总能量及蛋白质的摄入量的个体化方案,促使患者转变生活方式,最终实现长期临床结局和生活质量的改善。Diabetic nephropathy is one of the most common microvascular complications of diabetes. Its pathogenesis is unknown, which involves gene and genetic susceptibility, oxidative stress, adipokines and abnormal blood rheology. The course of disease, body mass index, blood lipid and glycosylated hemoglobin arc independent risk factors of diabetic nephropathy, while genetic susceptibility, inflammation, coagulation abnormalities, hypertension, hyperglycemia and hyperlipemia have played a role. An important means to delay the progression of the disease is medical nutrition therapy. Individual plans of the total energy and protein intake can be made according to patients＂ condition and treatment goals to promote the change of patients＂ lifestyle so as to achieve long-term clinical outcomes and improve their life quality.

关 键 词：2型糖尿病 肾病 高危因素 营养治疗 

分 类 号：R587.2[医药卫生—内分泌]