1-脱氧野尻霉素及其衍生物生物活性研究进展  

Progress in Research on Physiological Activity of 1-Deoxynojirimycin and Its Derivatives

作　　者：邓超[1] 吴昭全 刘芳[1] 曾光尧[1] 周应军[1] 

机构地区：[1]中南大学药学院,长沙410013

出　　处：《中国药学杂志》2017年第13期1110-1114,共5页Chinese Pharmaceutical Journal

基　　金：国家科技十一五重大专项-新药创制项目(2009ZX09102-110)

摘　　要：1-脱氧野尻霉素是一种多羟基生物碱,具有降糖、降脂、抗肿瘤、抗病毒等众多生理功能。随着研究的深入,对相关生物活性的解释愈加清楚,并且在这一过程中不断有新的生理活性被发现。因此笔者对近年来与1-脱氧野尻霉素(及其衍生物)生物活性有关的新发现进行总结,为1-脱氧野尻霉素的进一步研究及应用提供参考。1-Deoxynojirimycin（ DNJ）, a polyhydroxylated alkaloid, has demonstrated numerous physiological activites, such as anti-diabetes, lipid-lowering,anti-cancer and anti-virus effects. As research continues, related activities have been explained even more clearly, and new physiological activities have been found. In this review, new discoveries of the physiological activities of DNJ and DNJ derivatives were summarized. This will provide pharmaceutical basis for future study and application of DNJ.

关 键 词：1-脱氧野尻霉素 降糖 抗病毒 降脂 衍生物 

分 类 号：R284[医药卫生—中药学]