前列腺素合成酶基因调控与前列腺疾病关系的研究进展  

Gene regulation of prostaglandin synthase and prostate diseases

作　　者：吴双双[1,2,3,4] 吴建辉[1,2,3] 孙祖越[1,2,3] 

机构地区：[1]上海市计划生育科学研究所药理毒理学研究室中国生育调节药物毒理检测中心,上海200032 [2]国家人口和计划生育委员会计划生育药具重点实验室,上海200032 [3]复旦大学生殖与发育研究院,上海200032 [4]复旦大学药学院,上海201203

出　　处：《中华男科学杂志》2017年第7期663-667,共5页National Journal of Andrology

基　　金：上海市人才发展基金(201372);上海市科委研发公共服务平台项目(15DZ2290400)~~

摘　　要：前列腺素合成酶(PGS)能催化各种类型前列腺素的生成,调节相关物质的基因表达水平,其基因调控机制与前列腺疾病的发生和发展密切相关。目前有关PGS在前列腺疾病如良性前列腺增生(BPH)和前列腺癌(PCa)中调控机制的研究很少,鲜有研究直接对PGS基因调控与前列腺疾病关系进行探讨。本文拟对两者的关系进行分析,为从干预PGS调控途径防控BPH和PCa提供研发思路。Prostaglandin synthase （PGS） can catalyze the production of various types of prostaglandins and regulate the expres- sion levels of related substances. The regulation mechanisms of the PGS gene are closely related with the occurrence and development of prostate diseases. However, few studies are reported on the regulation mechanisms of PGS in prostatic diseases, such as benign pros- tatic hyperplasia （BPH） and prostate cancer （PCa）, or on the relationship between PGS gene regulation and prostate diseases. This review aims to analyze their correlation and provide some ideas for the prevention and control of BPH and PCa by intervention of the prostaglandin synthase regulatory pathway.

关 键 词：前列腺素合成酶 基因调控 良性前列腺增生 前列腺癌 

分 类 号：R697.3[医药卫生—泌尿科学]