细菌性重症肺炎患儿抗菌药物相关性腹泻发病率及高危因素分析  

Prevalence and risk factors of antibiotic associated diarrhea in children with severe bacterial pneumonia

作　　者：朱德胜[1] 曾方玲[1] 刘潇[1] 左超[1] 

机构地区：[1]湖南省儿童医院急救中心,湖南长沙410007

出　　处：《实用检验医师杂志》2017年第2期105-107,共3页Chinese Journal of Clinical Pathologist

摘　　要：目的探讨细菌性重症肺炎患儿抗生素相关性腹泻(AAD)发病的高危因素。方法选择2014年5月至2016年5月在本院重症监护室(ICU)接受治疗的1 226例细菌性重症肺炎患儿作为研究对象。将患儿按照是否出现AAD分为对照组和研究组,对照组900例,研究组患儿326例,分析患儿的AAD的发病率及高危因素。结果 1 226例患儿共使用9种抗菌药物,发病率为26.59%,其中阿莫西林/克拉维酸发病率为30.67%;年龄、机械通气、抗菌药物使用5 d、联用抗菌药物、阿莫西林/克拉维酸、哌拉西林/他唑巴坦及头孢哌酮/舒巴坦均为引发AAD的独立危险因素。结论细菌性重症肺炎患儿AAD的发病率较高,高危因素包括年龄、机械通气、抗菌药物使用5 d、联用抗菌药物、阿莫西林/克拉维酸、哌拉西林/他唑巴坦及头孢哌酮/舒巴坦等。Objective To investigate the incidence and risk factors of antibiotic associated diarrhea in children with severe bacterial pneumonia. Methods A total of 1 226 patients with severe bacterial pneumonia treated in our hospital from May 2014 to May 2016 were selected as the subjects. The children were divided into the control group and the study group according to whether AAD appeared, the control group 900 cases, the study group 326 eases. The incidence of antibiotics related diarrhea and high risk factors were analyzed. Results A total of 9 antibioties were used, with the incidence rate of 26.59%. The amoxicillin/elavulanate the incidence rate was 30.67%. The age, meehanical ventilation, the use of antibiotics, 5 days combined with antibiotics, amoxieillin/ clavulanate, piperaeillin/tazobactam and cefoperazone/shubatan were found to be independent risk factors. Conclusions Children with severe bacterial pneumonia antibiotic were eomplicated with diarrhea, and the risk factors include age, mechanical ventilation, the use of antibiotics, 5 days combined with antibiotics, amoxicillin/ clavulanate, piperacillin/tazobactam and eefoperazone/sulbactam.

关 键 词：细菌性重症肺炎 抗菌药物相关性腹泻 高危因素 

分 类 号：R725[医药卫生—儿科]