MicroRNA在脊髓损伤中的研究进展  

Research Progress of MicroRNA in Spinal Cord Injury(review)

作　　者：张文豪[1,2,3,4] 李建军[1,2,3,4] 杨德刚[1,2,3,4] 高品操 杨明亮[1,2,3,4] 杜良杰[1,2,3,4] 高峰[1,2,3,4] 唐芳 刘长彬[1,2,3,4] 李大鹏[1,2,3,4] 张鑫[1,2,3,4] 张洁[1,2,3,4] 

机构地区：[1]首都医科大学康复医学院,北京市100068 [2]中国康复研究中心北京博爱医院脊柱脊髓神经功能重建科,北京市100068 [3]北京脑重大疾病研究院神经损伤与修复研究所,北京市100068 [4]北京市神经损伤与康复重点实验室,北京市100068 [5]湖南医药学院,湖南怀化市418000

出　　处：《中国康复理论与实践》2017年第6期649-653,共5页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家自然科学基金面上项目(No.81272164);中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-6)

摘　　要：microRNA是能够调控靶基因表达的小分子RNA,在脊髓发育和脊髓损伤等过程的基因表达中具有重要作用,可能是促进脊髓损伤后神经再生和修复的治疗性干预新靶点,是脊髓损伤潜在的生物学标志物。本文从microRNA在脊髓损伤中的机制及热点microRNA方面做一综述。MicroRNAs are short non-coding RNAs that regulate and control the translation of target genes, and play an important role in gene expression involved in the development of spinal cord and spinal cord injury, which constitute novel targets for therapeutic intervention to promote repair and regeneration of the spinal cord, also they are the potential biomarkers of spinal cord injury. This article reviewed the mechanism of microRNAs and listed several microRNAs in spinal cord injury area.

关 键 词：脊髓损伤 MICRORNA 基因表达 转录调控 生物学标记 新靶点 综述 

分 类 号：R651.2[医药卫生—外科学]