辛伐他汀联合银杏叶片对心性猝死综合征患者的血脂及颈动脉粥样硬化斑块的影响  

Effects of simvastatin and Ginkgo tablets on plasma lipids and carotid atherosclerotic plaque in patients with sudden cardiac death syndrome

作　　者：赵丹生 马晓峰 

机构地区：[1]青海省红十字医院药学部,西宁810000 [2]青海省心脑血管病专科医院干部保健科,西宁810012

出　　处：《中国临床药理学杂志》2017年第13期1171-1173,共3页The Chinese Journal of Clinical Pharmacology

基　　金：青海省卫生计生科研基金资助项目(2016-wjqn-05)

摘　　要：目的研究辛伐他汀联合银杏片对心性猝死综合征患者血脂及颈动脉粥样硬化斑块的影响。方法随机选取患者300例,将患者随机分为2组(每组150例):试验组(辛伐他汀20 mg+联合银杏叶片24 mg)与对照组(辛伐他汀20mg),每次1片,1日3次,疗程均为6个月。治疗后,用生化法检测患者的血脂水平;以颈动脉彩色多普勒超声测量斑块面积。结果在治疗6个月后,试验组和对照组的总胆固醇(TC)分别为(3.67±0.45),(4.21±0.24)mmol·L^(-1);三酰甘油(TG)分别为(1.44±0.47),(2.00±0.68)mmol·L^(-1);高密度脂蛋白胆固醇(HDL-C)分别为(0.98±0.12),(0.90±0.13)mmol·L^(-1);低密度脂蛋白胆固醇(LDL-C)分别为(1.84±0.41),(2.17±0.49)mmol·L^(-1)。与治疗前比较,2组差异均有统计学意义(均P<0.05)。试验组的HDL-C水平显著高于对照组、而TC、TG、LDL-C水平低于对照组,差异均有统计学意义(均P<0.05)。治疗前,试验组和对照组的斑块面积分别为(6.70±3.56),(6.38±3.68)mm^2。治疗后,试验组和对照组的斑块面积分别为(4.21±2.16),(4.77±2.70)mm^2。2组的斑块面积虽然减少,但与治疗前比较,差异无统计学意义(P>0.05)。结论辛伐他汀联合银杏叶片对心性猝死综合征患者的TC、LDL-C、TG水平有降低作用并能够减少患者的斑块面积。Objective To study the effects of simvastatin and Ginkgo tablets on blood lipid and carotid atherosclerotic plaque in patients with sudden cardiac death syndrome（ SIDS）. Methods The 300 patients were randomly divided into two groups： treatment group（ simvastatin 20 mg ＋ Ginkgo tablets 24 mg） and control group（ simvastatin 20 mg）.Each group had 150 cases. Each one tablet,three times a day. The course of treatment in both groups were six months. During the course of treatment,the blood lipid level was measured once every three months by the biochemical detection method. After the treatment,the plaque area was measured by carotid color Doppler ultrasound. Results At the time 6 months after treatment,the levels of total cholesterol（ TC） in treatment group and control group were（ 3. 67 ± 0. 45）,（ 4. 21 ± 0. 24）mmol·L^（-1）; triacylglycerol（ TG） in that two groups were（ 1. 44 ± 0. 47）,（ 2. 00 ± 0. 68） mmol · L^（-1）; high densitylipoprotein-cholesterol（ HDL-C） in that two groups were（ 0. 98 ± 0. 12）,（ 0. 90 ± 0. 13） mmol·L^（-1）; and low densitylipoprotein-cholesterol（ LDL-C） in that two groups were（ 1. 84 ± 0. 41）,（ 2. 17 ± 0. 49） mmol·L^（-1）. Compared with before treatment and compared with control group after treatment,the difference was statistically significant（ all P〈0. 05）. Before treatment,the area of the plaques in the treatment group and control group were（ 6. 70 ± 3. 56）,（ 6. 38 ± 3. 68） mm^2. But after treatment,the area of the plaques in the treatment group and control group were（ 4. 21 ± 2. 16）,（ 4. 77 ± 2. 70） mm^2 with not statistically significant（ all P〈0. 05）. Conclusion Simvastatin combined with Ginkgo tablets could decrease TC,LDL-C and TG levels in patients with SIDS and reduce the plaque area.

关 键 词：辛伐他汀 银杏叶片 心性猝死综合征 颈动脉粥样硬化斑块 

分 类 号：R972.6[医药卫生—药品]