微小RNAs调控心肌细胞离子通道的研究现状  

Current situation of study of microRNAs on cardiomyocyte ion channels regulation

作　　者：赵育林[1] 林韬[1] 耿帅[1] 李潭[1] 姬莉[1] 龚冬梅[1] 

机构地区：[1]哈尔滨医科大学药理教研室,哈尔滨150081

出　　处：《中国临床药理学杂志》2017年第13期1260-1262,1266,共4页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81202523);黑龙江省高校战略后备人才出国研修基金资助项目(2013)

摘　　要：离子通道广泛分布于心肌细胞,是心脏产生电活动、发生兴奋-收缩耦联的基础,其异常改变会引起多种心血管疾病,如心律失常、心力衰竭等。近年来miRNAs在多种疾病调控中的作用成为研究热点。miRNAs对心血管系统疾病具有一定作用,并与离子通道关系密切,对miRNAs为靶点的药物研究正在进行中。本文主要综述通过干扰miRNAs来调控心肌细胞离子通道,尤其是有望作为药物作用新靶点的miRNAs。Ion channels are widely distributed in the cardiomyocytes and they are the electrical bases of cardiac excitement-contraction coupling.Abnormal changes of ion channel can lead to a variety of cardiovascular diseases,such as arrhythmia and heart failure. Recent years,several research have focused on the miRNA and diseases. Some of them suggested that miRNAs involved in the occurrence and development of cardiovascular diseases,which were closely related with ion channels. The function of ion channels would change along with the change of the miRNAs. The following paper reviewed that some miRNAs regulated myocardial ion channels according to the existing studies,especially those potent targets of drugs.

关 键 词：MIRNAS 离子通道 心血管疾病 

分 类 号：R97[医药卫生—药品]