内源性外泌体作为药物递释系统的研究进展  

Research Progress of Exosomes Used as Drug Delivery System

作　　者：赵嘉兰 王悦敏[1] 牛亚伟[1] 董晓婷[1] 秦凌浩[1] 

机构地区：[1]广东药科大学药剂系,广州510006

出　　处：《材料导报》2017年第13期160-165,共6页Materials Reports

基　　金：广东省自然科学基金(2014A030310362);广州市科技计划项目(201508010036);广州市产学研协同创新重大专项(201605131249066)

摘　　要：外泌体是一种活细胞分泌的直径为40~100nm的囊状小泡,是细胞间信息传递、物质交换的重要媒介。作为天然内源性的物质转运载体,采用外泌体负载药物具有毒性低、无免疫原性、渗透性好等优势,目前,外泌体已成功负载小分子化学药物、基因药物用于治疗肿瘤及阿尔茨海默症等疾病。文章将基于外泌体的发展情况就外泌体在药物递送系统中的应用进行详细的介绍分析。Exosomes are membrane vesicles secreted by living cells with size of 40--100 nm. Exosomes are very important natural messengers involving in cellular communication and substance transportation. As natural carriers for material transportation, exosomes have unique advantages including low toxicity, low immunogenicity and good permeability. So far, small molecular chemi- cal drugs and genetic drugs have been successfully delivered by exosomes for treating tumor disease and Alzheimer＇s disease. In this paper, a detailed review of exosomes used as drug delivery system is oresented based on recent researches

关 键 词：外泌体 载体 药物递送系统 肿瘤 

分 类 号：TB39[一般工业技术—材料科学与工程]