钩吻素子大鼠在体肠吸收动力学研究  

Study on intestinal absorption kinetics of koumine in rats

作　　者：石冬梅[1] 苏燕评[2] 俞昌喜[3] 

机构地区：[1]福建医科大学药学院天然药物学系,福州350122 [2]福建医科大学药学院药物化学系,福州350122 [3]福建医科大学药学院药理学系,福州350122

出　　处：《中国新药杂志》2017年第12期1450-1454,共5页Chinese Journal of New Drugs

基　　金：福建省自然科学基金资助项目(2013J01374)

摘　　要：目的:研究钩吻素子大鼠在体肠吸收动力学特征。方法:采用高效液相色谱法测定钩吻素子含量,以大鼠在体单向灌流法研究药物浓度、吸收部位和灌流液p H对钩吻素子肠吸收的影响。结果:小肠为钩吻素子主要吸收窗、十二指肠、空肠、回肠各段对钩吻素子的吸收无显著差异(P>0.05);钩吻素子吸收速率不受自身质量浓度影响,吸收机制符合被动扩散方式;钩吻素子在不同p H灌流液中吸收有显著性差异(P<0.05),碱性条件下钩吻素子吸收优于酸性条件。结论:钩吻素子在全肠段吸收良好,没有特定吸收窗口,提示该药物适合制成缓释制剂。Objective： To investigate the intestinal absorption kinetics of koumine in rats. Methods： In situ single-pass perfusion method was used to study the effect of drug concentration,absorption site and p H of perfusion solution on the absorption of koumine. The concentration of koumine was determined by HPLC. Results：The absorption rates of koumine in duodenum,jejunum and ileum were not significantly different（ P〉0. 05） and the intestinal absorption mechanism of koumine was passive diffusion. The concentration of koumine had no effect on its absorption,and the p H of perfusion solution had significant effect on it（ P〈0. 05）. Conclusion： Koumine is well adsorbed at all segments of intestine in rats where there is no special absorption site. Koumine is suitable to be developed as sustained-release preparation.

关 键 词：钩吻素子 在体单向灌流法 肠吸收动力学 高效液相色谱法 

分 类 号：R285.5[医药卫生—中药学]