Retromer localizes to autophagosomes during HCV replication  

作　　者：Peiqi Yin Zhi Hong Leiliang Zhang Youyang Ke 

机构地区：[1]MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College [2]Department of Emergency, 171st Hospital of PLA

出　　处：《Virologica Sinica》2017年第3期245-248,共4页中国病毒学（英文版）

基　　金：supported by grants from the National Natural Science Foundation of China(81471955,81672035,81301438);the CAMS Innovation Fund for Medical Sciences(CIFMS)(2016-I2M-3-020);the National Key Plan for Research and Development of China(2016YFD0500300);the Program for Changjiang Scholars and Innovative Research Team in University(IRT13007);the Fundamental Research Funds for the Central Universities,the PUMC Youth Fund(3332016085)

摘　　要：Dear Editor,Hepatitis C virus（HCV）is a positive-strand RNA virus that belongs to the genus Hepacivirus within the Flaviviridae family.HCV causes chronic liver diseases,and185 million people are infected（Messina et al.,2015）.Currently,there is no approved vaccine to prevent hepatitis C.HCV induces autophagy through elevating reactive oxygen species（ROS）levels via the unfolded protein response （UPR） or via direct interference with the autophagic pathway.Dear Editor,Hepatitis C virus(HCV)is a positive-strand RNA virus that belongs to the genus Hepacivirus within the Flaviviridae family.HCV causes chronic liver diseases,and185 million people are infected(Messina et al.,2015).Currently,there is no approved vaccine to prevent hepatitis C.HCV induces autophagy through elevating reactive oxygen species(ROS)levels via the

关 键 词：Flaviviridae replication belongs approved autophagy vaccine infected strand RNA cargo 

分 类 号：R373.21[医药卫生—病原生物学]