血清尿酸水平对冠状动脉痉挛的影响  

Effect of serum uric acid on coronary artery spasm

作　　者：盛臻强[1] 黎叶飞[1] 郑扣龙[1] 汪弢[1] 卢辉和[1] 

机构地区：[1]江苏省南通市第一人民医院心血管内科,南通226001

出　　处：《南通大学学报（医学版）》2017年第2期136-138,共3页Journal of Nantong University(Medical sciences)

基　　金：南通市卫计委科研项目(WQ2014001)

摘　　要：目的:探讨血清尿酸水平对冠状动脉痉挛的影响及机制。方法:冠状动脉造影提示冠状动脉无显著狭窄的胸痛患者58例,分为痉挛组(30例)和对照组(28例)。收集两组患者临床资料,检测患者血清尿酸及内皮依赖性舒张功能(flow-mediated dilation,FMD)。结果:两组临床基本资料对比差异无统计学意义,痉挛组血清尿酸水平高于对照组[(351.6±93.7)μmol/L vs(316.9±80.6)μmol/L,P<0.05],FMD低于对照组(4.08%±0.61%vs 7.17%±1.29%,P<0.05)。直线相关回归分析提示血清尿酸水平与FMD呈负相关(r=-0.398,P<0.05)。结论:冠状动脉痉挛患者血清尿酸水平升高,导致血管内皮功能减退,可能促进冠状动脉痉挛的发生。Objective： To observe the effect of serum uric acid on coronary artery spasm（CAS） and to discuss its mechanism of action. Methods： 58 patients with chest pain were divided into two groups, CSA group（n=30） and control group（n=28）. Serum uric acid level was detected by uricase method. Detail echocardiography was performed to assess the dilatation changes of flow-mediated dilation（FMD）. Results： The serum concentration of uric acid was significantly higher in CSA group than control group[（351.6±93.7） Ixmol/L vs （316.9±80.6） μmoi/L, P〈0.05], the level of FMD in CAS group was lower than control group （4.08%±0.61% vs 7.17%±1.29%, P〈0.05）. A negative correlation of serum uric acid concentrations was analyzed by linear regression with FMD（r=-0.398, P〈0.05）. Conclusions： Elevated serum uric acid content in patients with CSA lead to dys- function of the vascular endothelium, and promote the occurrence of CSA.

关 键 词：冠状动脉痉挛 尿酸 内皮依赖性舒张功能 

分 类 号：R541.4[医药卫生—心血管疾病]