感冒后哮喘发作患儿经小儿推拿干预后EOS、血清IL与IgE相关性研究  

The Correlation of EOS,IL and Ig E with Childhood Asthma Attack after Cold with Massage Intervention

作　　者：刘潇[1] 张伟[1] 杨丽珍[1] 朴圣爱[1] 柳琳琳[1] 张莹莹[1] LIU Xiao ZHANG Wei YANG Li - zhen PIAO Sheng - ai LIU Lin - lin ZHANG Ying - ying(The First Affiliated Hospital of Heilon~iang University of Chinese Medicine, Harbin 150040, China)

机构地区：[1]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《针灸临床杂志》2017年第6期15-17,共3页Journal of Clinical Acupuncture and Moxibustion

基　　金：黑龙江省自然基金面上项目;编号:H2015033;黑龙江中医药大学校基金项目;编号:201213

摘　　要：目的:探讨外周血嗜酸性粒细胞、白细胞介素、血清IgE与儿童感冒后哮喘发作的相关性,阐明经小儿推拿治疗后哮喘停止发作的机理。方法:将120例患儿随机分成两组,药物组(进行常规止喘药物治疗),推拿组(药物加推拿),每组60例,另外选择20例健康儿童作为对照组。分别检测药物组、推拿组治疗前后及对照组患儿血清中IgE、IL-33的水平以及外周血EOS水平,并进行相关性统计。结果:感冒后哮喘发作患儿治疗前血清中IgE、IL-33的水平、EOS数值均显著升高,与对照组比较(P<0.05);药物组、推拿组与治疗前比较患儿血清中IgE、IL-33的水平、EOS数值有显著降低(P<0.05);推拿组与药物组疗后比较(P<0.05),推拿组使患儿血清中IgE、IL-33的水平EOS数值有显著降低,优于药物组;患儿感冒后哮喘发作时血清IL-33水平与血清IgE、EOS绝对计数呈正相关(P<0.05)。结论:患儿血清中IgE、IL-33的水平以及外周血嗜酸性粒细胞水平增高与感冒后哮喘发作直接相关,其中IL-33发挥主导作用,推拿干预后可使上述指标下降而达到缓解哮喘发作的目的。Objective： To study the correlation of eosinophils（ EOS）,interleukin（ IL）,and IgE with childhood asthma attack after cold,and to clarify the mechanism of the massage intervention for this kind of disease.Methods： 120 children patients with asthma attack after a cold were randomly divided into the medication group（ conventional medication） and the massage group（ conventional medication ＋ massage）,with 60 patients in each group; another 20 healthy children were taken into the control group. The levels of IL-33 and IgE in plasma,and EOS in peripheral blood were detected in all groups before and after treatment to do the statistic analysis. Results： Before treatment,the levels of IL-33,IgE,and EOS significantly increased in the children patients compared to those in the healthy children（ P〈0. 05）; whereas they all significantly decreased after the interventions（ P〈0. 05）,of which the massage group was superior to the medication group（ P〈0. 05）. There was a positive correlation between the levels of IL-33,IgE,and EOS with asthma attack after cold. Conclusion： The increase of IL-33,IgE,and EOS is directly related to the asthma attack after cold,in which IL-33 was the main factor. Massage intervention may relieve asthma attack by reducing IL-33,IgE,and EOS.

关 键 词：感冒 哮喘 小儿推拿 白细胞介素-33 嗜酸性粒细胞 

分 类 号：R244.1[医药卫生—针灸推拿学]