1-三十烷醇的合成工艺改进  

Improvement on the Synthetically Process of 1-triacontanol

作　　者：李明[1] 张勇 王秋艳[1] 曹文婷[1] 原现瑞 LI Ming ZHANG Yong WANG Qiuyan CAO Wenting YUAN Xianrui(College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Hebei Shijiazhuang 050018,China State Key Laboratory Breeding Base-Key Laboratory of Molecular Chemistry for Drug of Hebei Province, Hebei Shijiazhuang 050018,China Biotechnology Company of Jizhou Zone Hengshui,Hehei Hengshui 053200,China)

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]河北省药用分子化学重点实验室-省部共建国家重点实验室培育基地,河北石家庄050018 [3]衡水市冀州区瑞天生物科技有限公司,河北衡水053200

出　　处：《河北师范大学学报（自然科学版）》2017年第4期334-338,共5页Journal of Hebei Normal University：Natural Science

基　　金：河北省引进留学人员资助项目(C2013003018)

摘　　要：1-三十烷醇是一种有效的植物生长调节剂.设计了一条新的1-三十烷醇的合成路线,以1,12-十二烷二醇和溴代十八烷为起始原料,通过选择性保护羟基、选择性氧化伯醇成醛、十八烷基三苯基溴化膦钅翁盐制备、维悌希反应和加氢还原等5步化学反应,制备得到1-三十烷醇,重结晶后产品纯度在98%以上.1-triacontanol is an efficient plant growth regulator.In this paper,a new organic synthetic process was designed to prepare 1-triacontanol through 5-step reactions,starting from 1,12-dodecanediol and octadecyl bromide.One hydroxyl group of 1,12-dodecanediol was selectively protected by TBDMSCl,and the other one was oxidized to get 12-tert-butyl dimethyl silanyloxydodecanal.Octadecyl bromide reacted with triphenyl phosphonium to get octadecyl triphenyl phosphonium bromide.Wittig reaction was carried out with the two intermediates.The product（olefin）was reduced by hydrogen and then the protective group TBDMS was removed to yield 1-triacontanol.After recrystalization,the GC purity of 1-triacontanol was over 98 percent.

关 键 词：1-三十烷醇 1 12-十二烷二醇 溴代十八烷 维悌希反应 

分 类 号：R979.9[医药卫生—药品]