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机构地区:[1]兰州大学第一医院生殖医学专科医院,甘肃730000
出 处:《中国优生与遗传杂志》2017年第7期41-42,共2页Chinese Journal of Birth Health & Heredity
摘 要:目的探讨常规体外受精-胚胎移植(IVF)组和卵胞浆内单精子显微注射(ICSI)组早期流产者绒毛染色体异常情况的不同。方法 IVF组103例、ICSI组84例和自然受孕组53例绒毛组织进行贴壁培养,收获后行染色体核型分析。结果 IVF组、ICSI组与对照组绒毛染色体异常核型检出率分别为34.95%、48.81%、30.19%,差异无显著性意义(P﹥0.05);女性≥35岁组中绒毛染色体异常核型检出率ICSI组与对照组差异有显著性意义(P﹤0.05)。结论大于35岁妇女在ICSI术时胚胎更易发生染色体异常,建议对接受试管婴儿治疗的35岁以上妇女,尽可能采用常规IVF。Objective: To compare cytogenetic results occurring with first trimester in conventional IVF (in vitro fertilization) and ICSI (intracytoplasmic sperm injection) . Methods: Karyotype analysis of villus tissue, patients were grouped by type of conception as follows: conventional IVF (n=103) , ICSI (n=84) , and control (natural conception or intrauterine insemination) (n=53) . Results: 1) Chromosome aberration of villus rates were similar in the ICSI vs. conventional IVF vs. control groups. 2) In women aged≥ 35 years, statistically significantly differences were observed between ICSI and control groups. Conclusions: Chromosome aberration of villus rates of ICSI was increase in women aged≥35 years. The IVF have priority for medical choice over ICSI in women aged≥ 35 years.
关 键 词:绒毛染色体 常规体外受精-胚胎移植 卵胞浆内单精子显微注射
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