孕妇血PLGF、EPO含量与子痫前期的关系  

Relationship between PLGF and EPO levels in maternal blood with preeclampsia

作　　者：陶春梅[1] 初晓丽[1] 郭海香[1] 刘艳丽[1] 张大微[1] 

机构地区：[1]广州医科大学附属沙井医院产科,广东深圳518104

出　　处：《中国优生与遗传杂志》2017年第7期71-72,共2页Chinese Journal of Birth Health & Heredity

基　　金：深圳市宝安区科技计划社会公益(医疗卫生类)立项项目(编号2015232)

摘　　要：目的探讨孕妇外周血胎盘生长因子(PLGF)及促红细胞生成素(EPO)与子痫前期的发病关系。方法用ELISA方法测定外周中PLGF、EPO水平,并记录胎儿出生体重,分析其与子痫前期的关系。结果子痫前期患者外周血PLGF的表达均明显的低于对照组(P<0.05),且与疾病的严重程度相一致;子痫前期患者外周血EPO的表达均明显的高于对照组(P<0.05),且与疾病的严重程度相一致。结论孕妇血PLGF水平、EPO与子痫前期病情呈相关性,PLGF、EPO参与子痫前期的发生发展,研究PLGF、EPO可能为子痫前期的早期诊断和治疗提供新的方法。Objective： To explore the relationship between placental growth factor （PLGF） and erythropoietin （EPO） in the peripheral blood of pregnant women with preeclampsia. Methods： The levels of PLGF and EPO in peripheral blood were determined by ELISA method, and the birth weight was recorded, and analysis their relationship with preeclampsia. Results： The expression of PLGF in the peripheral blood of patients with preeclampsia was significantly lower than that in the control group （P〈0.05） , and being consistent with the severity of the disease. The expression of EPO in the peripheral blood of patients with preeclampsia was significantly higher than that in the control group （P〈0.05） , and being consistent with the severity of the disease. Conclusion： The level of serum PLGF and EPO in maternal blood were correlated with the severity of preeclampsia, and PLGF and EPO were involved in the occurrence and development of preeclampsia. The study of PLGF and EPO may provide a new method for early diagnosis and treatment of preeclampsia.

关 键 词：子痫前期 胎盘生长因子 促红细胞生成素 

分 类 号：R714.244[医药卫生—妇产科学]