P小体与病毒感染  

Processing bodies and virus infection

作　　者：张林月[1] 陈思佳[1] 郎秀娟 顾生风 王燕[1] 

机构地区：[1]哈尔滨医科大学基础医学院微生物学教研室,150081

出　　处：《国际遗传学杂志》2017年第3期183-186,共4页International Journal of Genetics

基　　金：黑龙江省卫生计生委科研课题（2014-409）

摘　　要：P小体（Processing bodies，PBs）是细胞质中存在的，含有多种功能相关蛋白和RNA的胞浆复合物，主要参与mRNA降解和基因沉默，在基因表达过程中起到了重要的调控作用。在病毒感染过程中，细胞发生一系列应对反应，P小体与病毒之间发生相互作用。一方面，P小体会抑制病毒RNA在细胞内的合成，影响病毒基因组的转录、翻译及定位等过程，降解病毒RNA。另一方面，一些病毒可以利用P小体中的某些成分来促进自身复制，保证其在细胞内存活，不被细胞降解。P小体的相关功能可以帮助宿主抵抗病毒感染，动态调节细胞的生命进程。Processing bodies （ PBs ） are cytoplasmic complexes that are rich in a variety of func- tion-related proteins and RNA and play a critical regulatory role in the process of gene expression. In the process of viral infection, a series of responses occur in the cells, during the interaction between PBs and the virus. On the one hand, PBs inhibit the synthesis of viral RNA in the cell, and affect the viral genome transcription, translation and localization processes such as degradation of viral RNA. On the other hand, some viruses can use some PBs to promote their own replication, to ensure its survival without degradation in the cell. As a host defense mechanism, PBs-related functions play an important role in viral infection and the dynamic regulation of cell life process.

关 键 词：P小体 病毒 相互作用 

分 类 号：R373[医药卫生—病原生物学]