肉苁蓉不同提取部位对便秘大鼠通便作用的影响  

Purge functions of different extraction parts of C.deserticola against constipation rat model

作　　者：范亚楠[1] 王佳 贾天柱[1,2,3] 拉斯卡 史辑[1,2,3] FAN Ya-nan WANG Jia JIA Tian-zhu LA SI-KA SHI Ji(School of Pharmacy, Liaoning Uni versity of Traditional Chinese Medicine, Liaoning Dalian 116600, China Key Laboratory of Analysis of Processing Princi ple, State Administration of Tradition Chinese Medicine, Liaoning Dalian 116600, China Liaoning Research Center of Tra ditional Chinese Medicine Processing Engineering, Liaoning Dalian 116600, China)

机构地区：[1]辽宁中医药大学药学院,辽宁大连116600 [2]国家中医药管理局炮制原理解析重点研究室,辽宁大连116600 [3]辽宁省中药炮制工程技术研究中心,辽宁大连116600

出　　处：《中国医院药学杂志》2017年第13期1256-1258,共3页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金青年基金(编号:81001635);国家自然科学基金(编号:81473350)

摘　　要：目的:研究肉苁蓉不同提取部位的润肠通便作用。方法:使用易蒙停建立大鼠便秘模型,计算便秘大鼠6 h的粪便粒数和重量,并观察、测定便秘大鼠的胃肠激素和肠神经递质等指标。结果:肉苁蓉不同提取部位有促进便秘大鼠排泄作用,与模型组比较,总寡糖部位组SS、AchE、SP、MTL有升高的趋势,总寡糖部位组5-HT、VIP、NT显著升高(P<0.05或P<0.01),AQP3显著降低(P<0.01),表明总寡糖组有明显的治疗效果,其余各组无显著性差异,提示总寡糖是肉苁蓉有效作用部位。结论:肉苁蓉的总寡糖具有较好的润畅通便作用,能有效治疗便秘,可为其开发提供科学依据。OBJECTIVE To investigate the laxative effects of different extracted parts of C.deserticola.METHODS Imodium constipation rat model was established to observe defecation,and determine gastrointestinal hormones and neurotransmitters,etc.RESULTS Different extracted parts of C.deserticola had promoting effects to constipating excretion of rats.Compared with model group,SS,AchE,SP and MTL of gosaccharide part tended to rise,5-HT,VIP and NT of oligosaccharide part significantly increased（P0.05 or P0.01）,AQP3 significantly reduced（P0.01）,which suggested that the oligosaccharide part had obvious therapeutic effects.The remaining parts showed no significant difference.Oligosaccharide was an effective working part of C.deserticola.CONCLUSION The oligosaccharide of C.deserticola has good purging effects,and can effectively treat constipation,which provides the scientific basis for pharmaceutical development.

关 键 词：肉苁蓉 通便 胃肠激素 肠神经递质 总寡糖 

分 类 号：R285.5[医药卫生—中药学]