冠状动脉粥样硬化性心脏病患者细胞毒素相关蛋白基因A幽门螺杆菌感染状况研究  

Prevalence of cytotoxin-associated gene A Helicobacter pylori infection in patients with coronary atherosclerotic heart disease

作　　者：张丽[1] 张保朝[2] 王璐[1] 郭遂成[3] 常方圆[4] 丁春丽[1] 

机构地区：[1]南阳医学高等专科学校第一附属医院心血管内科,河南南阳473058 [2]南阳市中心医院神经内科,河南南阳473009 [3]南阳医学高等专科学校第一附属医院消化内科,河南南阳473058 [4]聊城市第二人民医院心内一科,山东临清252600

出　　处：《中华医院感染学杂志》2017年第13期2928-2931,共4页Chinese Journal of Nosocomiology

摘　　要：目的探讨冠状动脉粥样硬化性心脏病患者细胞毒素相关蛋白基因A(CagA)幽门螺杆菌(HP)感染状况,为冠状动脉粥样硬化性心脏病的防治提供参考。方法选取2015年6月-2016年6月诊治的冠状动脉粥样硬化性心脏病患者100例(冠心病组)和同期门诊行健康体检的健康人群100例(对照组),采用酶联免疫吸附法检测HP-IgG抗体、抗HP-CagA-IgG抗体,14C呼气试验检测HP。结果冠心病组HP感染、CagA HP感染分别为75例(75.00%)、51例(51.00%),对照组分别为12例(12.00%)、2例(2.00%),比较差异有统计学意义(P<0.05);冠心病组1-2支冠状动脉病变患者HP感染、CagA HP感染分别有53例、31例,感染率分别为69.74%、40.79%,≥3支病变患者分别有22例、20例,感染率分别为91.67%、83.33%,比较差异有统计学意义(P<0.05);冠心病组稳定性冠心病患者HP感染、CagA HP感染分别为33例(63.46%)、17例(32.69%),急性冠脉综合症患者分别为42例(87.50%)、34例(70.83%),比较差异有统计学意义(P<0.05);冠心病组冠状动脉轻中度狭窄患者HP感染、CagA HP感染分别为49例(68.06%)、29例(40.28%),重度狭窄患者分别为26例(92.86%)、22例(78.57%),比较差异有统计学意义(P<0.05)。结论冠状动脉粥样硬化性心脏病患者CagA HP感染率高,CagA HP感染与患者病变严重程度密切相关。OBJECTIVE To explore the prevalence of cytotoxin-associated gene A（CagA）Helicobacter pylori infection in patients with coronary atherosclerotic heart disease so as to provide guidance for prevention and treatment of coronary atherosclerotic heart disease.METHODS Totally 100 patients with coronary atherosclerotic heart disease who were treated from Jun 2015 to Jun 2016 were chosen as the coronary heart disease group,and 100 healthy people who received physical examination in outpatient department were set as the control group.The HPIgG antibody and anti HP-CagA-IgG antibody were detected by means of enzyme-linked immunosorbent assay,and H.pylori was detected with the use of 14 Cbreath test.RESULTS There were 75（75.00%）patients with H.pylori infection and 51（51.00%）patients with CagA H.pylori infection in the coronary heart disease group,and there were 12（12.00%）patients with H.pylori infection and 2（2.00%）patients with CagA H.pylori infection in the coronary heart disease group（P〈0.05）.Among the patients with 1-2coronary arteries lesions in the coronary heart disease group,there were 53（69.74%）patients with H.pylori infection and 31（40.79%）patients with CagA H.pylori infection;among the patients with no less than 3coronary arteries lesions,there were 22（91.67%）patients with H.pylori infection and 20（83.33%）patients with CagA H.pylori infection,the differences were significant（P〈0.05）.Among the patients with stable coronary heart disease in the coronary heart disease group,there were 33（63.46%）patients with H.pylori infection and 17（32.69%）patients with CagA H.pylori infection;among the patients with acute coronary syndrome,there were 42（87.50%）patients with H.pylori infection and 34（70.83%）patients with CagA H.pylori infection,the differences were significant（P〈0.05）.Among the patients with mild to moderate coronary artery stenosis in the coronary heart disease group,there were 49（68.06%）patients with H.pylori infection and 29（40.28%）pat

关 键 词：冠状动脉粥样硬化性心脏病 细胞毒素相关蛋白基因A 幽门螺杆菌 

分 类 号：R543.3[医药卫生—心血管疾病]