雷公藤多苷联合替米沙坦对糖尿病肾病患者肾功能和血流变的影响  

Effect of tripterygium wilfordii polyglycoside combined telmisartan on renal function and hemorheology in patients with diabetic nephropathy

作　　者：涂传发 王丽君[1] 顾玲佳[1] 陶海英[1] TU Chuan-fa WANG Li-jun GU Ling-jia et al.(Department of Endocrinology and Me- tabolism, Huangyan Hospital, Wenzhou , Zhefiang 318020, China)

机构地区：[1]温州医科大学附属黄岩医院内分泌代谢科,浙江温州318020

出　　处：《中华全科医学》2017年第9期1527-1528,1595,共3页Chinese Journal of General Practice

摘　　要：目的探讨雷公藤多苷联合替米沙坦对糖尿病肾病患者肾功能和血流变的影响。方法以随机数字法将2014年6月—2016年1月温州医科大学附属黄岩医院收治的216例糖尿病肾病患者随机分为2组,每组108例。对照组给予替米沙坦,观察组在对照组的基础上加用雷公藤多苷。治疗前后,检测患者肾功能指标[尿β2微球蛋白(β2-MG)、24 h尿微量白蛋白排泄率(UAER)、24 h尿蛋白定量(UP)、肾小球滤过率(GFR)]、血液生化指标[血白细胞(WBC)、血清肌酐(Scr)、尿素氮(Bun)、糖化血红蛋白(Hb A1c)]、血液流变[血浆黏度(PV)、纤维蛋白原(PF)、全血高切黏度(HBV)、全血低切黏度(LBV)];并统计2组的治疗效果。结果治疗后,2组β2-MG、UAER、UP、GFR水平均明显降低(P<0.05),且观察组β2-MG、UAER、UP、GFR水平改善情况优于对照组(P<0.05)。治疗后,2组WBC、Scr、Bun、Hb A1c水平均明显改善(P<0.05),且观察组WBC、Scr、Bun、Hb A1c水平的改善显著优于对照组(P<0.05)。治疗后,2组PV、PF、HBV、LBV水平均明显改善(P<0.05),且观察组PV、PF、HBV、LBV水平的改善显著优于对照组(P<0.05)。治疗后,观察组治疗总有效率为90.7%,显著高于对照组的79.6%(P<0.05)。结论雷公藤多苷联合替米沙坦可有效改善糖尿病肾病患者肾功能和血液微循环,治疗效果满意。Objective To investigate the effect of tripterygium wilfordii polyglycosides combined tehnisartan on renal function and hemorheology in patients with diabetic nephropathy. Methods Two hundred and sixteen cases of diabetic nephropathy were randomly divided into two groups, with 108 cases in each group. The patients in the control group re- ceived telmisartan, while the patients in the observation group received additional tripterygium wilfordii polyglycosides. Be- fore and after the treatment, the renal function indicators （Urine β2-MG, UAER, UP and GFR）, blood biochemical indica- tors （ WBC, Scr, Bun, HbA1 c）, hemorheology （ PV, PF, HBV, LBV） of both groups were detected. And the total effective rate of two groups were accounted. Results After the treatment, β2-MG, UAER, UP and GFR levels of both groups were significantly improved（ P 〈 0.05 ） , and the β2-MG, UAER, UP and GFR improvements of the observation group were sig- nificantly better than those of the control group（ P 〈 0.05 ）. After the treatment, WBC, Scr, Bun and HbA1 c levels of both groups were significantly improved（ P 〈 0. 05 ） , and the WBC, Scr, Bun and HbA1 c improvements of the observation group were significantly better than those of the control group（ P 〈 0. 05 ）. After the treatment, PV, PF, HBV and LBV levels of both groups were significantly improved （ P 〈 0. 05 ）, and the PV, PF, HBV and LBV improvements of the observation group were significantly better than those of the control group（ P 〈 0.05 ）. The total effective rate of the observation group was 90.7 % , which was significantly higher than that of control group （ 79.6 % , P 〈 0.05 ）. Conclusion Tripterygium wil- fordii polyglycoside combined with telmisartan could effectively improve the renal function and hemorheology of patients with diabetic nephropathy,with satisfactory effect.

关 键 词：雷公藤多苷 替米沙坦 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]