基于年龄分层的血瘀证患者急性脑梗死发病相对危险度病例对照Mantel-Haenszel分析  

Relative Risk of Cerebral Infarction in Blood Stasis Patients Based on Age Stratification : Case Control Mantel-Haenszel Analysis

作　　者：程南方[1] 谭峰[1] 刘效仿[2] 程馨缘[3] 詹杰[1] 谭玖清[1] 许青[1] 陈嘉慧[1] 

机构地区：[1]广州中医药大学附属佛山中医院脑病科,广东528000 [2]广州中医药大学附属佛山中医院骨科,广东528000 [3]云南中医学院研究生院,昆明650500

出　　处：《中国中西医结合杂志》2017年第7期804-806,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金面上项目(No.81473470);广东省自然科学基金重点项目(No.1414050000195);广东省博士启动项目(No.2016A030310239);佛山市院市合作项目(No.2014HT10004);佛山市高校和医院科研基础平台建设项目(No.2013AG10009)

摘　　要：目的观察不同年龄伴有血瘀证患者急性脑梗死(ACI)发病的相对危险度,探讨血瘀对ACI发病的影响及二者相关性。方法将167例ACI患者及161名健康对照者依据辨证分型标准分为血瘀组及非血瘀组,观察血瘀组患者ACI发病优势比(OR),并进行基于年龄分层的病例对照Mantel-Haenszel分析。结果血瘀与ACI发病呈正相关(OR为5.965,P<0.05);年龄是ACI发病正混杂因素,控制年龄因素后,血瘀者ACI发病风险是非血瘀者的5.931倍(P<0.01)。结论血瘀与ACI发病密切相关,是本病重要危险因素与基本病机。Objective To observe odds ratio （OR） of acute cerebral infarction （ACI） occurrence in blood stasis patients of different ages, and to observe the effect of blood stasis on the pathogenesis of ACI and their correlations. Methods Totally 167 ACI patients and 161 healthy controls were assigned to the blood stasis group and the non-blood stasis group by syndrome differentiation. OR of ACI was observed in the blood stasis group. Case control Mantel-Haenszel analysis was performel based on age. Results Blood stasis and the incidence of ACI was positively correlated （OR =5.965, P 〈0.05）. Age was positive confounding factor in ACI incidence. If age factor is controlled, the risk of suffering from ACI in blood stasis patients was 5.931 times of non-blood stasis subjects （P 〈0.01 ）. Conclusions Blood stasis is closely related to the incidence of ACI. It is both the key risk factor and basic pathogenesis.

关 键 词：血瘀 脑梗死 相对危险度 Mantel-Haenszel分析 

分 类 号：R277.7[医药卫生—中医学]