慢性肾脏病肾组织FA值与a-SMA表达的相关性研究  

Correlation between FA value and α-SMA of renal tissue in patients with chronic kidney disease

作　　者：卢军丽[1] 朱瑾[2] 赵建[1] 于荭[1] 马晓晖[1] 张伟[1] 李英[3] 

机构地区：[1]河北医科大学第三医院放射科,河北石家庄050051 [2]天津中医药大学第一附属医院功能检查科,天津300193 [3]河北医科大学第三医院肾内科,河北石家庄050051

出　　处：《实用放射学杂志》2017年第7期1056-1058,共3页Journal of Practical Radiology

摘　　要：目的 评价慢性肾脏病（CKD）患者肾实质各向异性分数（FA）值与肾组织a-SMA表达的相关性.方法 对33例CKD患者进行3.0T MR肾脏扫描,扫描序列包括MRI常规扫描及扩散张量成像（DTI）.在FA图上分别测量双侧肾脏皮质及髓质的FA值.其中有24例患者进行了肾组织活检.免疫组织化学法检测肾活检标本中a-SMA蛋白的表达,计算每个视野内阳色染色区域的积分光密度值,其平均值用于统计学分析.分别对肾皮质及肾髓质的FA值与免疫组织化学a-SMA的积分光密度值的相关性进行Bivariate相关分析.结果 肾皮质FA值与a-SMA的积分光密度值之间呈显著负相关（P=0.001）.肾髓质FA值与a-SMA的积分光密度值之间呈显著相关性（P=0.035）.结论 MR DTI获得的FA值与肾组织a-SMA表达具有相关性.Objective To assess the correlation between fractional anisotropy（FA） value and α-SMA of renal tissue in patients with chronic kidney disease （CKD）.Methods 33 CKD patients underwent MRI standard scanning and diffusion tensor imaging（DTI）.FA values were measured on both medulla and cortex of bilateral kidneys on the FA map.24 patients were performed renal biopsy to detect the expression of α-SMA.The integrated optical density of positive-staining region was calculated for each view.The relationship between the FA values and the integrated optical densities of α-SMA was analyzed by using Bivariate correlation analysis.Results There was a significant negative correlation between the cortical FA values and the integrated optical densities of α-SMA （P=0.001）.There was a significant negative correlation between the medullary FA values and the integrated optical densities of α-SMA （P=0.035）.Conclusion FA value of DTI was correlated with α-SMA of renal tissue in patients with CKD.

关 键 词：慢性肾脏病 磁共振成像 扩散张量成像 各向异性分数 A-SMA 

分 类 号：R692[医药卫生—泌尿科学] R445.2[医药卫生—外科学]