食蟹猴自发性高血压及患病危险性的相关性研究  

Spontaneous hypertension in cynomolgus monkeys and an analysis of its risk factors

作　　者：徐湘婷[1] 韦祝梅 李振明 罗绍忠[1] 向黎[1] 张常弘[1] 杨继红[1] 杨淬[3] 

机构地区：[1]昆明医科大学药学院暨省天然药物药理重点实验室,云南昆明650500 [2]广西玮美生物科技有限公司,广西南宁530105 [3]云南民族大学民族药资源化学国家民委-教育部重点实验室,云南昆明650500

出　　处：《中国比较医学杂志》2017年第6期1-5,共5页Chinese Journal of Comparative Medicine

基　　金：国家"十二五"重大新药创制专项(编号:2011ZX09307-303);广西科技计划项目(编号:桂科能14123006-7);广西科技计划项目(编号:桂科攻1347003-3)

摘　　要：目的建立各年龄段食蟹猴血压参考值。方法采用美国Beckman-CX4全自动生化分析仪和北京松下电工有限公司的腕式电子血压计,检测521只食蟹猴血压及血脂指标,对测定结果进行统计检验。结果经统计分析,不同年龄段的食蟹猴血压值差异显著,老年组食蟹猴血压值高于其它年龄组;老年组食蟹猴高血压的发病率高于其他年龄组,高血压组食蟹猴身体质量指数(body mass index,BMI)高于同年龄组血压正常的食蟹猴;老年组高脂血症食蟹猴高血压发病率高于其他年龄组。Logistic回归分析显示,年龄、BMI及高脂血症在预测高血压组的患病危险性的预测能力分别为血压正常组的1.435、1.218、2.337倍。结论初步建立不同年龄段食蟹猴的血压参考值。年龄、BMI、高脂血症为食蟹猴自发性高血压的危险因素,基础血压值测量为食蟹猴自发性高血压模型筛选及其相关研究提供了依据。Objective To establish reference values for blood pressure in cynomolgus monkeys in different ages.Methods The blood pressures and blood lipids indexes were detected in 521 cynomolgus monkeys using an American BECKMAN-CX4 automatic biochemical analyzer and a wrist electronic blood pressure monitor. Statistical tests were performed to analyze the data. Results Significant differences were found in blood pressure values of cynomolgus monkeys in different ages. Blood pressure values in the elderly group were higher than those of other groups. The morbidity of hypertension in the elderly group was higher than those of the other groups. Body mass index（ BMI） in the hypertension group was higher than that of normal group in the same age. The incidence of hypertension in the elderly group withhyperlipemia was higher than that of other groups. Logistic regression analysis showed that age,BMI and hyperlipidemia in the hypertensive group were 1. 435,1. 218,and 2. 337 times higher than those of the normal group when predicting the risk of hypertension. Conclusions We have initially established reference values of blood pressure in cynomolgus monkeys in different ages. Age,BMI and hyperlipidemia are risk factors of spontaneous hypertension in cynomolgus monkeys,and the measurement of blood pressure may provide a basis for the screening of cynomolgus monkey model of spontaneous hypertensive and related research.

关 键 词：食蟹猴 高血压 BMI 

分 类 号：R33[医药卫生—人体生理学]