C肽检测对2型糖尿病周围神经病变患者辨证治疗与预后判断的指导意义  

Significance of C Peptide Detection in Diagnosis and Treatment of Type 2 Diabetic Peripheral Neuropathy

作　　者：罗露露[1] 刘振杰[1] 蓝柳贵[1] 王丘平[1] 吴丽燕[1] 范冠杰[1] 

机构地区：[1]广东省中医院内分泌科,广东广州510120

出　　处：《辽宁中医杂志》2017年第7期1434-1436,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：广东省中医院综合标准化试点重点示范项目立项资助课题(YN2015BZ07)

摘　　要：目的:探讨C肽检测对2型糖尿病周围神经病变(DPN)患者辨证治疗与预后判断的指导意义。方法:2013年2月—2016年6月选择在本院内分泌科住院和门诊的2型糖尿病患者300例,其中2型糖尿病周围神经病变组(A组)147例,2型糖尿病非周围神经病变组(B组)153例,两组都进行中医辨证分型,同时进行C肽检测与相关性分析。结果:A组患者多为阴阳两虚(夹瘀)证和气阴两虚(夹瘀)证,而B组患者多为气虚(夹瘀)证和阴虚热盛(夹瘀)证,两组辨证分型构成比对比有明显差异(P<0.05)。A组的C肽含量分别为(0.31±0.11)μg/L,都明显低于B组的(0.68±0.13)μg/L(P<0.05)。气阴两虚证、阴阳两虚证与C肽的相关程度大于阴虚热盛与气虚证,都存在明显相关性(P<0.05)。Logistic回归分析显示DPN患者的气阴两虚证、阴阳两虚证和C肽水平为主要的独立危险因素(P<0.05)。结论:C肽检测有利于2型糖尿病周围神经病变患者的中医辨证分型,能有效判断病情,对指导治疗与预后分析具有一定意义。Objective：To explore the significance of C peptide detection in the diagnosis and treatment of type 2 diabetic peripheral neuropathy（DPN） patients.Methods：From February 2013 to June 2016,300 inpatients and outpatients with type 2 diabetes at the Department of Endocrinology in our hospital were selected：147 cases of type 2 diabetes peripheral neuropathy group（group A）,153 cases of type 2 diabetes non peripheral neuropathy group（group B）.The two groups were given the TCM syndrome differentiation typing and the C peptide detection and correlation analysis.Results：The group A of patients were more with Qi Yin deficiency and yin deficiency heat syndrome,and group B were more Yin and yang deficiency syndrome and yin deficiency and heat syndrome that compared the two groups were significantly different（P〈0.05）.The contents of C peptide in group A were（0.31±0.11） μg/L respectively,and both were significantly lower than that of group B of（0.68±0.13） μg/L（P〈0.05）.Spearman correlation analysis results showed that Yin and yang deficiency syndrome were more related to the C peptide compared to the Yin and yang deficiency syndrome and yin deficiency and heat syndrome that there all had significant correlation（P〈0.05）;Logistic regression analysis results show the Yin and yang deficiency syndrome,Yin and yang two deficiency syndrome and C peptide levels were the risk factors in patients with DPN（P〈0.05）.Conclusion：C peptide detection is beneficial to type 2 diabetic peripheral neuropathy patients with TCM syndrome differentiation.It also can effectively determine the condition,guide the treatment and prognosis analysis and also has a certain significance.

关 键 词：C肽 2型糖尿病周围神经病变 中医辨证分型 预后判断 

分 类 号：R587.2[医药卫生—内分泌]