人白血病相关蛋白16在垂体泌乳素腺瘤患者中的表达及其与雌激素受体α表达水平的相关性分析  

Expression of leukemia-related protein 16 and the correlation to the estrogen receptor α levels in patients with prolactin adenomas

作　　者：苏星[1] 王安平[1] 宋志刚[1] 赵坤[1] 郭清华[1,2] 母义明[1] 

机构地区：[1]解放军总医院内分泌科,北京100853 [2]解放军总医院海南分院内分泌科,海南三亚572013

出　　处：《解放军医学杂志》2017年第7期603-607,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金(81270866;81570705)~~

摘　　要：目的探讨人白血病相关蛋白16(LRP16)在垂体泌乳素腺瘤患者中的表达情况及其与雌激素受体α(ERα)表达水平的关系。方法选取2009年10月-2014年9月于解放军总医院神经外科术中切除并经病理证实的31例成人垂体泌乳素腺瘤标本(观察组)和22例成人非垂体泌乳素腺瘤标本(对照组)。免疫组织化学法检测两组标本的泌乳素(PRL)、LRP16和ERα表达水平。结果垂体泌乳素腺瘤30岁以下患者以女性多见,30岁以上患者以男性多见,且男性垂体泌乳素腺瘤患者均为肥胖或超重;31例垂体泌乳素腺瘤中有26例(83.9%,26/31)LRP16为阳性表达,明显高于非垂体泌乳素腺瘤组(22.7%,5/22),有28例(90.3%,28/31)ERα为阳性表达,明显高于非垂体泌乳素腺瘤组(31.8%,7/22)。垂体泌乳素腺瘤中LRP16与ERα的表达量和表达强度的变化趋势均同步,二者存在一定正相关关系。结论高体重指数(BMI)可能是男性垂体泌乳素腺瘤发生发展和预后不良的高危因素;LRP16可能通过ERα参与了垂体泌乳素腺瘤的增殖与形成。Objective To study the expression of leukemia-related protein 16（LRP16） in human pituitar y prolactin adenomas（PRL adenomas）, and the relationship between LRP16 and estrogen receptor α（ERα）. Methods From October 2009 to September 2014, thirty-one adult patients diagnosed and pathologically confirmed as pituitary prolactin（PRL） adenomas（observation group） and 22 pituitary non-PRL adenomas（control group） in the Chinese PLA General Hospital were verified by the pathological examination. Immunohistochemical method was used to detect the expression levels of LRP16, PRL and ERα. Results Of the patients in observation group, those aged under 30 were predominantly females, while male patients were more common in those aged over 30. LRP16 positively existed in 26 cases（83.9%, 26/31）, and ERα was positive in 28 cases（90.3%, 28/31）, the both ratios were significantly higher than those in control group. ERα and LRP16 increased synchronously both in expressive content and intensity, showing a certain positive correlation between them. Conclusions Higher body mass index may be a high-risk factor badly affected the occurrence, development and prognosis in male patients with pituitary PRL; LRP16 may take part in the proliferation and formation of pituitary PRL adenomas through ERα.

关 键 词：垂体泌乳素腺瘤 雌激素受体Α 白血病相关蛋白16 泌乳素 

分 类 号：R584[医药卫生—内分泌]