胸水CEA、CD40、CYFR21-1对良、恶性胸水的鉴别诊断价值  

The value of pleural effusion indicators in differential diagnosis between benign and malignant hyolrothorax

作　　者：王凊[1] 车续春 

机构地区：[1]天津医科大学总医院检验科,天津300052 [2]天津医科大学

出　　处：《中国实验诊断学》2017年第7期1151-1153,共3页Chinese Journal of Laboratory Diagnosis

基　　金：天津医科大学科学基金面上项目(2015KYZM12)

摘　　要：目的探讨胸水指标对良、恶性胸水鉴别诊断价值,并尝试确定诊断截点值。方法选择2014年6月至2016年6月我院初诊的合并胸水的非小细胞肺癌患者的临床资料,并列为观察组。另选取50例良性胸水患者为对照组。采用酶联免疫吸附法检测并对比两组患者胸水CEA、CD40及CYFR21-1的水平。结果研究共纳入观察组患者53例,对照组50例。观察组患者胸水CEA、CD40、CYFR21-1水平均显著高于对照组(P<0.05)。ROC曲线分析显示,以28.28pg/ml为截点值,CD40诊断恶性胸水的敏感性为86.00%,特异性为90.00%,曲线下面积为0.89,优于CYFR21-1及CEA。结论恶性胸水中CEA、CD40及CYFR21-1水平显著升高,对鉴别良恶性胸水有一定价值,其中CD40的鉴别诊断敏感性及特异性均较佳。Objective Our study was aimed to analyze the value of pleural effusion indicators in differential diagnosis between benign and malignant hyolrothorax.Methods Clinical data of patients with non-small cell lung cancer received treatment at our hospital from 2014 to 2016were analyzed as Group A.Patients with benign pleural effusions were enrolled as Group B.The levels of CEA,CD40 and CYFR21-1in hydrothorax were tested and compared between the two groups by ELISA.Results A total of 103 patients were analyzed,Group A 53 cases,Group B 50 cases.Group A patients had higher levels of CEA,CD40 and CYFR21-1in hydrothorax than these of Group B patients,the difference was statistically significant（P〈0.05）.ROC analysis showed that the CD40cut-off point value of 28.28pg/ml,as used for the differential diagnosis between benign and malignant hyolrothorax,provided a sensitivity of 86.00%,a specificity of90.00%,an AUC of 0.89,better than these of CYFR21-1and CEA.Conclusion CD40 can be used as an differential diagnosis index between benign and malignant hyolrothorax.

关 键 词：非小细胞肺癌 胸水 鉴别诊断 肿瘤标志物 

分 类 号：R561.4[医药卫生—呼吸系统] R734.2[医药卫生—内科学]