一氧化氮合酶抑制剂对七叶莲花镇痛作用的影响  

Effects of nitric oxide synthase inhibitor on the analgesic effects induced by Schefflera arboricola Hayata flower

作　　者：孙爱静[1] 庞素秋[1] 陈滟湄 

机构地区：[1]解放军第180医院临床药学科,泉州362000

出　　处：《东南国防医药》2017年第3期231-233,共3页Military Medical Journal of Southeast China

基　　金：南京军区医药卫生科研基金(15MS114)

摘　　要：目的探讨一氧化氮合酶(NOS)抑制剂与七叶莲花镇痛作用的关系。方法采用小鼠热板法,将小鼠随机分为等渗盐水组(阴性对照组)、曲马多组(阳性对照组)及各实验组,观察L-精氨酸(L-Arg)和NOS抑制剂L-硝基精氨酸甲酯(L-NAME)对七叶莲花醇提物(SAHF)镇痛作用的影响。结果与等渗盐水组比较,L-NAME可显著增强七叶莲花的镇痛作用(P<0.01);与SAHF组比较,脑组织中NO水平显著降低(P<0.05)。结论七叶莲花的镇痛作用和NOS抑制剂之间存在一定的相互作用,L-NAME可显著增强七叶莲花的镇痛作用,提示SAHF的镇痛作用机制与降低体内过量的NO有关。Objective To explore the relationship of Schefflera arboricola Hayata flower（ SAHF） and nitric oxide synthase（ NOS） inhibitor on the analgesia. Methods Mice were randomly separated into the normal saline group（ negative control group）,tramadol group（ positive control group） and experimental groups. The analgesic effects of SAHF were observed by hot-plate test,and L-Arg and nitric oxide synthase inhibitor（ L-NAME） were administered in combination with SAHF to study the influence on the antianalgesia effect. Results Contrasted with the normal saline group,L-NAME can enhance the analgesic action of SAHF（ P〈0.01）,and contrasted with SAHF group,L-NAME can reduce the level of nitric oxide in the brain（ P〈0.05）. Conclusion SAHF has significant analgesic effects, which may be related with excessive nitric oxide, and the analgesia of SAHF could be augmented by L-NAME.

关 键 词：七叶莲花 一氧化氮合酶 L-硝基精氨酸甲酯 镇痛作用 

分 类 号：R285.5[医药卫生—中药学]