胶质母细胞瘤瘤周脑区异质性研究进展  

Research progress on heterogeneity of peritumoral brain zone in glioblastoma multiforme

作　　者：王军[1] 杨晨[1] 龙浩[1] 杨开军[1] 王海[1] 俞磊[1] 李志勇[1] 漆松涛[1] 

机构地区：[1]南方医科大学南方医院神经外科,广东广州510515

出　　处：《转化医学电子杂志》2017年第7期11-15,共5页E-Journal of Translational Medicine

基　　金：国家自然基金面上项目(81372692);南方医科大学留学回校扶持项目(LX2016N006);"科技开发培育计划"项目(KJ20161102)

摘　　要：胶质母细胞瘤是颅内最常见的原发恶性肿瘤,最大安全范围的手术切除联合术后放化疗是目前标准治疗方案.但是,胶质母细胞瘤容易复发,90%以上的胶质母细胞瘤在瘤周脑区复发,即肿瘤周边的脑水肿区域.肿瘤本身及遗传特性的异质性导致胶质母细胞瘤的个体差异较大.研究发现,瘤周脑区同样具有异质性,且瘤周脑区的异质性可能与肿瘤的复发有密切的联系.本文重点介绍胶质母细胞瘤瘤周脑区异质性的研究进展,尤其是其在影像组学、细胞构成和分子生物学的特征性表现,探讨瘤周脑区的异质性对优化手术切除以及靶向治疗的可能性.Glioblastoma multiforme （GBM） is the most common and most malignant primary brain tumour. Surgical resection to the maximum safety degree, combined with postoperative radiotherapy and chemotherapy, is the standard therapy for GBM. However, the postoperative recurrent rate is still high, and 90% recurrences occur in the peritumoral brain zone（PBZ）, which is defined as a peripheral oedematous region around GBM. The heterogeneity of the tumour itself and the individual genetic characteristics will lead to large heterogeneity in GBM. Moreover, some studies find that heterogeneity is also presented in PBZ. Further more, hetero- geneity of PBZ may be closely related to the tumour recurrence. This paper will review the study progress on peritumoral brain zone heterogeneity in glioblastoma muhiforme, in particular, describing the radiological, cellular, and molecular characteristics of PBZ, and further discuss the possibility of applying peritumoral brain zone heterogeneity in optimizing degree of surgical resection as wen as developing targeted therapies against GBM.

关 键 词：胶质母细胞瘤 精准医疗 瘤周脑区 影像组学 

分 类 号：R739.41[医药卫生—肿瘤]