术中放疗技术在高级别胶质瘤中的应用前景  

Application prospect of intraoperative radiotherapy in high grade glioma

作　　者：潘灏[1] 王汉东[1] 孙康健[1] 

机构地区：[1]南京军区南京总医院神经外科,江苏南京210002

出　　处：《转化医学电子杂志》2017年第7期77-79,共3页E-Journal of Translational Medicine

基　　金：国家自然科学基金青年项目(81402072);江苏省自然科学基金青年项目(BK20140732);57批中国博士后科学基金面上资助(2015M572716)

摘　　要：高级别胶质瘤具有增殖快、易复发等特点,临床上即使采取最大范围切除及术后放疗加同步辅助化疗,以及抗血管治疗、免疫治疗等众多新技术,治疗效果依然不佳.高级别胶质瘤的原位复发多为治疗失败的重要原因.术中放疗技术可以在术中针对瘤床或残存肿瘤进行直视下的精确单次大剂量照射,对于肿瘤原位复发控制具有较好的效果,目前在多种肿瘤中已有广泛的应用.本文就术中放疗技术作一简介,并对其在胶质瘤治疗中的理论基础、应用现状及前景进行文献回顾.The prognosis of high grade glioma is still very poor even through standard surgery, radiotherapy and chemotherapy. The most important reasons of treatment failure for high grade glioma is in situ recurrence. Intraoperative radiotherapy provides precise high dose irradiation directly to tumor bed after tumor resection, which has been proved to be effective in control of tumor recur- rence in situ. Here we briefly introduce the intraoperative radio- therapy and review its theoretical basis, application and prospect in high grade glioma treatment.

关 键 词：术中放疗 胶质瘤 原位复发 

分 类 号：R739.41[医药卫生—肿瘤]