脊髓损伤动物模型研究进展  

Research Progress in Animal Models of Spinal Cord Injury

作　　者：刘国库[1] 艾宗勇 牛宝华[1] 李天晴[1] 

机构地区：[1]昆明理工大学灵长类转化医学研究院,云南昆明650500

出　　处：《药物生物技术》2017年第3期279-282,共4页Pharmaceutical Biotechnology

摘　　要：脊髓损伤(Spina cord injury,SCI)是脊柱损伤最严重的并发症,是一种严重的神经系统功能障碍性疾病,损伤后会导致损伤节段以下肢体发生严重的功能障碍,最典型的表现为损伤部位以下瘫痪,这不仅会给损伤患者本人带来身体与心理上的严重伤害,还会对家庭以及社会造成巨大的经济负担。然而,目前对于脊髓损伤的研究仍然存在着很多问题,文章总结了近年来有关脊髓损伤动物模型的研究进展,并对于利用干细胞移植治疗脊髓损伤的方法进行综述。Spinal cord injury （SCI） is the most serious complication of spinal injury. It is a serious dysfunction of the neurological diseases. After the injury, it can cause serious dysfunction of the lower limber. The most typical manifestation is the following parts of the injured paralysis ,which will not only bring damage to the patient on physical and psychological aspects, but also give the family and society a huge financial burden. However,there are still many problems in the study of spinal cord injury. This paper summarizes the research progress of animal model of spinal cord injury in recent years, and the methods of using stem cell transplantation to treat spinal cord injury.

关 键 词：脊髓损伤 脊髓损伤模型 细胞移植 胚胎干细胞 神经干细胞 人脐带血干细胞 骨髓间充质干细 胞 脂肪来源干细胞 

分 类 号：R683.2[医药卫生—骨科学] R68[医药卫生—外科学]