前纤维蛋白1与心血管疾病的研究进展  

Research Advancement of Profilin-1 in Cardiovascular Disease

作　　者：杨达峰[1] 蒋敏娜 陈美芳[2] 杨天伦[1] 

机构地区：[1]中南大学湘雅医院心内科,长沙410008 [2]中南大学湘雅医院老干科,长沙410008

出　　处：《医学综述》2017年第14期2710-2714,共5页Medical Recapitulate

基　　金：国家自然科学基金(81570334;81370320);中南大学博士生自主探索创新项目(2015zzts111)

摘　　要：前纤维蛋白1(pfn-1)是一种在进化过程中高度保守的小分子关键肌动蛋白调节蛋白,其主要通过调控肌动蛋白的聚合与解聚介导细胞的收缩及运动。除肌动蛋白外,pfn-1还可以通过其结构域与磷脂酰肌醇和一系列富含多聚脯氨酸的蛋白质相互作用,进而将细胞外的信号与细胞骨架的动态改变整合,参与物质的跨膜运输、信号转导等重要的生理过程。同时,pfn-1的表达在多种心血管疾病中异常升高,并且与病情程度和细胞功能状态存在关联,pfn-1可能成为心血管疾病潜在的治疗靶点。Profilin-1 （ pfn-1 ） is a highly conserved and key actin regulator protein in evolution; its main function is to mediate cell contraction and motion through regulating the actin polymerization and depolymerization. In addition to actin, pfn-1 can also bind to phosphoinositides and a heterogeneous group proteins harboring poly-L-proline stretches through its binding domain, thereby integrates signaling from a diverse array of extracellular cues with actin cytoskeleton dynamics and participates in various important physiological processes including membrane trafficking and signal transduction. The expression of pfn-1 is elevated in multiple cardiovascular diseases and associated with progression of disease and cell function,which indicates that pfn-1 may serve as a potential therapeutic target in cardiovascular diseases.

关 键 词：心血管疾病 前纤维蛋白1 肌动蛋白 

分 类 号：R541[医药卫生—心血管疾病] R543[医药卫生—内科学]