间充质干细胞治疗胰腺炎的研究进展  

Research of Mesenchymal Stem Cells in the Therapy of Pancreatitis

作　　者：王得春[1] 郑建伟[1] 万晨光[1] 叶航羊[1] 赵瑞宁[1] 杜富波[1] 

机构地区：[1]西藏军区总医院肝胆外科,拉萨850007

出　　处：《医学综述》2017年第14期2720-2724,共5页Medical Recapitulate

摘　　要：胰腺炎是一种临床上常见的危及人类健康的疾病。其中,轻症急性胰腺炎多为自限性疾病,预后较好;然而重症急性胰腺炎多伴有胰腺的出血、坏死,合并多器官功能衰竭,发展迅速,病死率高。慢性胰腺炎多伴有胰腺不可逆性病理改变,导致胰腺内外分泌功能障碍。虽然随着医疗技术及治疗理念的不断进步,胰腺炎的治愈率有了一定程度的提高,然而目前仍没有一种真正有效的治疗手段来治愈此病。间充质干细胞(MSCs)具有低免疫原性和免疫调节的特性,同时还具有多向分化、定向迁移、组织修复的能力。此外,MSCs对炎性损伤具有较好的修复作用。由此可见,MSCs可能对胰腺炎所致的炎性损伤同样具有比较理想的治疗效果。Pancreatitis is a clinically common disease that threatens human health. Among them,mild acute pancreatitis is mostly self-limiting disease with a better prognosis. However, severe acute pancreatitis is often accompanied by hemorrhage and necrosis of the pancreas, with multiple-organ failure, which develops rapidly and has a high fatality. Chronic pancreatitis is often accompanied by irreversible pancreatic pathological changes, leading to pancreatic exocrine and secretory dysfunction. With the development of medical technology and treatment concept, the cure rate of pancreatitis has been improved to a certain extent, however, there is still no effective treatment to cure the disease. Mesenchymal stem cells （MSCs） have the characteristics of low immunogenicity and immunoreguiation, and they also have the ability of multi-directional differentiation, directional migration and tissue repair. In addition, MSCs has a good repair effect on inflammatory injury. Thus, MSCs may be equally effective in the treatment of inflammatory lesions induced by pancreatitis.

关 键 词：间充质干细胞 急性胰腺炎 慢性胰腺炎 重症急性胰腺炎 

分 类 号：R318.14[医药卫生—生物医学工程] R576[医药卫生—基础医学]