支气管动脉灌注化疗联合栓塞术治疗中心型非小细胞肺癌疗效观察  

Therapeutic effects of bronchial arterial perfusion chemotherapy combined with embolization on advanced central type non-small cell lung cancer

作　　者：赵仰光 

机构地区：[1]河北省秦皇岛市第四医院介入科,066000

出　　处：《河北医药》2017年第16期2432-2435,共4页Hebei Medical Journal

摘　　要：目的观察支气管动脉灌注化疗联合栓塞术治疗中心型非小细胞肺癌的临床疗效。方法 90例中心型非小细胞肺癌患者随机分为对照组和试验组,每组45例。对照组给予全身静脉化疗,试验组给予支气管动脉灌注化疗联合栓塞术治疗。比较2组近期疗效、远期疗效、不良反应、并发症发生情况、满意度及治疗前后患者血清肿瘤标志物[癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、神经特异性烯醇化酶(NSE)]、炎性因子[肿瘤坏死因子-α(TNF-α)、C-反应蛋白(CRP)、白介素-6(IL-6)]、T淋巴细胞亚群(CD_3^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+)变化。结果试验组近期疗效、远期疗效、满意度较对照组明显提高,不良反应、并发症发生率较对照组明显降低,差异有统计学意义(P<0.05)。2组治疗后CEA、CA125、CA19-9、NSE、TNF-α、CRP、IL-6、CD_8^+均较治疗前明显降低,CD_3^+、CD_4^+、CD_4^+/CD_8^+均较治疗前明显升高,差异有统计学意义(P<0.05),且试验组以上指标变化明显优于对照组(P<0.05)。结论支气管动脉灌注化疗联合栓塞术治疗中心型非小细胞肺癌能够明显提高患者生存率,有效改善患者细胞免疫失衡状态,降低炎性因子水平,且无明显不良反应。Objective To observe the therapeutic effects of bronchial arterial perfusion chemotherapy combined with embolization on advanced central type non-small cell lung cancer. Methods Ninety patients with advanced central type non-small cell lung cancer were randomly divided into control group and trial group,with 45 patients in each group. The patients in control group were treated by systemic intravenous chemotherapy,however,the other 45 patients in trial group were treated by bronchial arterial perfusion chemotherapy combined with embolization. The short-term curative effect,long-term curative effects,adverse effects,complications,satisfaction degree and the changes of levels of CEA,CA125,CA19-9,NSE,TNF-α,CRP,IL-6,CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋before and after treatment were observed and compared between two groups.Results The short-term curative effect,long-term curative effects and satisfaction degree in trial group were much better than those in control group,moreover,the adverse effects and complications in trial group were significantly less than those in control group（ P〈0.05）. After treatment the levels of CEA,CA125,CA19-9,NSE,TNF-α,CRP,IL-6 and CD8^＋were significantly decreased,as compared with those before treatment,however,the levels of CD3^＋,CD4^＋and CD4^＋/CD8^＋were obviously increased in both groups,as compared with those before treatment（ P〈0.05）,moreover,these indexes mentioned above in trial group were superior to those in control group（ P〈0.05）. Conclusion The bronchial arterial perfusion chemotherapy combined with embolization in treatment of advanced central type non-small cell lung cancer can obviously increase survival rate of patients,improve effectively cellmediated immunity imbalance state, decrease the levels of inflammatory cytokines,without obvious adverse effects.

关 键 词：支气管动脉灌注 栓塞 非小细胞肺癌 疗效 

分 类 号：R734.2[医药卫生—肿瘤]