糖类抗原125对急性心力衰竭诊断及临床预后的预测作用  

Role of carbohydrate antigen 125 on the diagnosis and prognosis of acute heart failure

作　　者：乔华[1] 李国民[2] 何胜虎[3] 李益民[4] 李穗吉[1] 

机构地区：[1]江苏大学附属金坛医院心内科,常州213200 [2]江苏大学附属金坛医院重症医学科,常州213200 [3]江苏省苏北人民医院心内科,扬州219100 [4]南京市胸科医院心内科,210029

出　　处：《中国心血管杂志》2017年第3期186-189,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨血清糖类抗原125(CA125)在诊断急性心力衰竭及判断其临床预后中的价值。方法选取2015年8月至2016年8月在江苏大学附属金坛医院和江苏省苏北人民医院心内科就诊的173例急性心力衰竭患者,按照纽约心脏病协会(NYHA)分级分为心功能Ⅲ级和Ⅳ级组,同时选取50名健康体检者作为对照组。比较各组的N末端B型利钠肽原(NT-proBNP)、高敏C反应蛋白(hs-CRP)和CA125水平,分别与超声心动图参数做相关性分析,观察各组患者住院期间死亡率。结果与对照组相比,急性心力衰竭患者的NT-proBNP、hs-CRP和CA125水平均显著升高,并且随着NYHA心功能分级的增高而升高,差异有统计学意义(P<0.01)。CA125、hs-CRP、左心室舒张末内径(LVEDD)水平与NT-proBNP呈正相关(r=0.401、0.316、0.445,均为P<0.01),左心室射血分数(LVEF)与NT-proBNP呈负相关(r=-0.642,P<0.01)。结论急性心力衰竭患者的CA125水平升高,可作为诊断心力衰竭的重要指标,且对于预测临床预后具有重要意义。Objective To investigate the value of serum carbohydrate antigen 125（ CA125） in the diagnosis of acute heart failure and its clinical prognosis. Methods From August 2015 to August 2016,173 patients with acute heart failure in the Department of Cardiology of Jintan Hospital Affiliated to Jiangsu University and Jiangsu Province Subei People＇ s Hospital were enrolled in this study. According to the New York Heart Association（ NYHA） classification,they were divided into NYHA class Ⅲ or class Ⅳ group. Fifty healthy subjects were selected as the control group as well. The blood levels of N-terminal pro B-type natriuretic peptide（ NT-proBNP）,high-sensitivity C-reactive protein（ hs-CRP） and CA125 in each group were measured and compared,correlation analysis with parameters of echocardiography and the mortality rate of patients in each group were observed. Results Compared with the control group,the levels of BNP,hsCRP and CA125 were significantly increased in patients with acute heart failure,and gradually increased with the increase of NYHA heart function classification. The difference was statistically significant（ P 0. 01）.CA125 and hs-CRP levels and left ventricular end diastolic diameter（ LVEDD） were positively correlated with NT-proBNP（ r = 0. 401,0. 316,0. 445,all P 0. 01）,left ventricular ejection fraction（ LVEF） was negatively correlated with NT-proBNP（ r =-0. 642,P 0. 01）. Conclusions CA125 levels is elevated in patients with acute heart failure and can be used as an important index in the diagnosis of heart failure and for prediction of the clinical prognosis.

关 键 词：血清糖类抗原125 急性心力衰竭 左心室射血分数 预后 

分 类 号：R541.6[医药卫生—心血管疾病]