抗菌药物致血液系统不良反应分析  

Adverse reactions in hematological system induced by antibacterial agents

作　　者：谢法红[1] 黄智 张浩榆 李德东[1] 

机构地区：[1]解放军总医院药学部临床药学中心,北京100853

出　　处：《药学实践杂志》2017年第4期298-300,314,共4页Journal of Pharmaceutical Practice

基　　金：国家自然科学基金(81501730)

摘　　要：近年来,随着抗菌药物在临床上的广泛应用,抗菌药物相关不良反应也越来越引起人们的关注。其中,由于抗菌药物所引起的血液系统不良反应严重影响了患者的身体健康和医生的药物选择。例如,部分β-内酰胺类抗生素可以引起凝血功能障碍和溶血性贫血,氯霉素、磺胺等可以引起再生障碍性贫血,利奈唑胺可以引起血小板减少和贫血等。正确认识各种抗菌药物所引起的血液系统不良反应及其机制,对于临床抗菌药物的选择具有重要意义。本文针对临床常见抗菌药物引起的血液系统不良反应及其机制进行综述,以期为临床抗菌药物的选择提供参考。In recent years , with the wide use of antimicrobial agents , the adverse reactions related to antimicrobial a - gents have attracted more and more attention .Among them , the adverse reactions in hematological system induced by antibacte - rial agents seriously affect patient s health and doctor s selection for antibiotics .For example, some beta lactam antibiotics can cause dysfunction of coagulation and hemolytic anemia .Chloramphenicol and sulfonamides can cause aplastic anemia .Linezolid can cause thrombocytopenia and anemia .It is important to understand the adverse reactions in hematological system caused by antibiotics .In this paper,the antibiotic induced adverse reactions in hematological system and their mechanism were summarized in order to provide information for the rational use of antimicrobial agents .

关 键 词：抗菌药物 血液系统 不良反应 

分 类 号：R978.1[医药卫生—药品]