PTP1B作为药物靶点的研究进展  

Development of PTP1B as a Drug Target

作　　者：张雪莲[1] 郑海洲[1] 郑智慧[1] 

机构地区：[1]华北制药集团新药研究开发有限责任公司,石家庄市新药筛选技术工程实验室,石家庄050015

出　　处：《国外医药（抗生素分册）》2017年第4期173-178,共6页World Notes on Antibiotics

基　　金：基金项目:微生物来源药物发酵及分离纯化中试条件建设及质量管理体系建设

摘　　要：Protein tyrosine phosphatase 1B(PTP1B)是治疗2型糖尿病以及肥胖的潜在的,有效的靶点。最近,其作为抗肿瘤的靶点得到了很多关注。这篇文章简要介绍了PTP1B在不同疾病相关信号通路中的作用以及人们在发现PTP1B抑制剂上已经取得的成果。目前,以PTP1B为靶点的小分子药物发现仍面临很多困难,经过努力,希望在不久的将来会找到更有潜力并且更加有效的PTP1B临床抑制剂药物。Protein tyrosine phosphatase 1B （PTP1B） is an effective target for the treatment of both type 2 diabetes and obesity. It has recently received attention as an unexpected targetfor cancer. In this review, we highlight the implication of PTP1B in signaling path in different diseases and progress that has been made in the development of potent and selective PTP1B inhibitors. Now, targeting PTP1B for drug discovery is still a challenging task. Future efforts will probably transform the potent and selective PTPl R inhibitors into effective drugs.

关 键 词：PTP1B PTP1B抑制剂 2型糖尿病 肥胖 肿瘤 

分 类 号：R96[医药卫生—药理学]