Spiro(phosphoamidite) ligand(SIPHOS)/Cu(OTf)2-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water  

作　　者：Qing-Qing Xuan Ya-Hui Wei Qiu-Ling Song 

机构地区：[1]Institute of Next Generation Matter Transformation, College of Chemical Engineering and College of Material Sciences at Huaqiao University, Xiamen 361021,China

出　　处：《Chinese Chemical Letters》2017年第6期1163-1166,共4页中国化学快报（英文版）

摘　　要：The highly regio-and stereoselective hydroborations of unactivated internal alkynes with diboron compound catalyzed by Cu（OTf）2 with spiro（phosphoamidite） as ligand in the presence of Cs2CO3 in water was developed.This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylboranes.The highly regio-and stereoselective hydroborations of unactivated internal alkynes with diboron compound catalyzed by Cu（OTf）2 with spiro（phosphoamidite） as ligand in the presence of Cs2CO3 in water was developed.This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylboranes.

关 键 词：Unactivated internal alkynes Diboron compound Spiro（phosphoamidite） ligand Aqueous synthesis Multi-substituted vinylboranes 

分 类 号：O621.251[理学—有机化学]