Six-step synthesis of Leonurine and toxicity study on zebrafish  

作　　者：Hui Zhao Xiang-Guo Hu Min-Jie Xu Qun-Xing Cai Yu-Jun Liu Duo-Meng Su Shi-Jin Chen Kai Wang Zhu-Nan Gong 

机构地区：[1]Anhui Engineering Technology Research Center for Extraction and Isolation of Active Components, Anhui Academy of Applied Technology, Hefei 230031,China [2]National Engineering Research Center for Carbohydrate Synthesis, Jiangni Normal University, Nanchang 330022, China [3]School of Life Science, Nanjing Normal University, Nanjing 210023, China [4]Anhui Academy of Science and Technology, Hefei 230031, China

出　　处：《Chinese Chemical Letters》2017年第6期1172-1175,共4页中国化学快报（英文版）

基　　金：supported by Anhui Ph.D.Programs of Postdoctoral Workstation,Talents Program of Hefei;funds from the sixth group of Anhui '115' Industrial Innovation Team(Team of Key Technology Innovation on Botanical Pesticides)

摘　　要：Leonurine（1）,an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass production.Commercially available compound 6 and 2,3-dihydrofuran（7） were used as starting materials.And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.Leonurine（1）,an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass production.Commercially available compound 6 and 2,3-dihydrofuran（7） were used as starting materials.And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.

关 键 词：Leonurine Zebrafish Synthesis Toxcity Oxime 

分 类 号：R285.5[医药卫生—中药学] TQ460.1[医药卫生—中医学]