Chromium-catalyzed asymmetric synthesis of 1,3-diols  

作　　者：Hong-Tao Ji Qing-Shan Tian Jian-Nan Xiang Guo-Zhu Zhang 

机构地区：[1]College of Chemistry and Chemical Engineering,Hunan University [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences

出　　处：《Chinese Chemical Letters》2017年第6期1182-1184,共3页中国化学快报（英文版）

基　　金：NSFC(Nos.21421091,XDB20000000);the "Thousand Plan" Youth program for financial support

摘　　要：An efficient,chromium-catalyzed highly enantioselective preparation of protected 1,3-diols has been achieved.In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand,a variety of optically pure 1,3-diols were synthesized in 34%-87%yields with up to 98%ee.The benzyl as well as silyl ethers were suitable substitutions for the hydroxyl group.Meanwhile,aromatic,aliphatic and α,β-unsaturated aldehydes are well tolerated under the mild reaction conditions.An efficient,chromium-catalyzed highly enantioselective preparation of protected 1,3-diols has been achieved.In the presence of a chiral chromium catalyst using the carbazole-based bisoxazoline as the chiral ligand,a variety of optically pure 1,3-diols were synthesized in 34%-87%yields with up to 98%ee.The benzyl as well as silyl ethers were suitable substitutions for the hydroxyl group.Meanwhile,aromatic,aliphatic and α,β-unsaturated aldehydes are well tolerated under the mild reaction conditions.

关 键 词：1 3-Diol Asymmetric Chromium-catalyzed Allylation Bisoxazoline 

分 类 号：O621.251[理学—有机化学]