Three new dimeric diterpenes from Rhododendron molle  

作　　者：Shuai-Zhen Zhou Chun-Ping Tang Chang-Qiang Ke Sheng Yao Ge Lin Yang Ye 

机构地区：[1]State Key Laboratory of Drug Research, and Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences,Shanghai 201203, China [2]SIMM-CUHK Joint Research Laboratory for Promoting Globalization of Traditional Chinese Medicines between Shanghai Institute of Materia Medica, ChineseAcademy of Sciences and The Chinese University of Hong Kong, China [3]School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China [4]School of Life Science and Technology. ShanghaiTech University, Shanghai 201203, China

出　　处：《Chinese Chemical Letters》2017年第6期1205-1209,共5页中国化学快报（英文版）

基　　金：financial support of the National Science & Technology Major Project "Key New Drug Creation and Manufacturing Program"(Nos.2012ZX09301001-001,2015ZX09103002);the National Natural Science Fundation of China(Nos.81302657,81473112,81573305)

摘　　要：Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.Birhodomolleins A-C（1-3）,three novel diterpenoids dimerized from two grayanane diterpenes through an oxygen bridge,were isolated from the flowers of Rhododendron molle.Their structures were elucidated by interpretation of their 1D and 2D NMR and other spectroscopic data.Birhodomollein A（1） contains a rare chloro-substitution on one of the grayanane moieties.These are the first examples of dimeric diterpenes from the Ericaceae family.

关 键 词：Rhododendron molle Ericaceae Dimeric diterpene Grayanane Birhodomolleins A-C 

分 类 号：TQ464.2[化学工程—制药化工]