Synthesis and insecticidal evaluation of phytoalexin phenalenones derivatives  

作　　者：Ya-Nan Zhang Yi-An Feng Zhong Li Xu-Sheng Shao 

机构地区：[1]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 20037, China

出　　处：《Chinese Chemical Letters》2017年第6期1228-1231,共4页中国化学快报（英文版）

基　　金：financial supported by National Natural Science Foundation of China(Nos.21472046,21372079);Science and Technology Commission of Shanghai Municipality(No.16391902300)

摘　　要：Phenalenone is a kind of defensive compound biosynthesized inside plants in response to the outside attack such as fungus and nematodes.A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were synthesized through introduction of phenyl and hydroxy!substitutes at 9-positon and 2-position and assessed their insecticidal activities against armyworm（Mythimna separata Walker） and cowpea aphids[Aphis craccivora）.No obvious insecticidal activities of the synthesized compounds were observed against armyworm.Some of the 9-phenyl and 2-hydroxy substituted phenalenone analogues showed potential activities against cowpea aphids with 33%-41%mortality at 500 mg/L.Phenalenone is a kind of defensive compound biosynthesized inside plants in response to the outside attack such as fungus and nematodes.A set of derivatives encompassing structural modifications on the privileged phenalenone scaffold were synthesized through introduction of phenyl and hydroxy!substitutes at 9-positon and 2-position and assessed their insecticidal activities against armyworm（Mythimna separata Walker） and cowpea aphids[Aphis craccivora）.No obvious insecticidal activities of the synthesized compounds were observed against armyworm.Some of the 9-phenyl and 2-hydroxy substituted phenalenone analogues showed potential activities against cowpea aphids with 33%-41%mortality at 500 mg/L.

关 键 词：Phenalenones derivatives Insecticidal activities Structural modifications 

分 类 号：TQ453[化学工程—农药化工]