Design,synthesis and insecticidal activities of novel anthranilic diamides containing fluorinated groups as potential ryanodine receptors activitors  

作　　者：Chang-Chun Wu Bao-Lei Wang Jing-Bo Liu Wei Wei Yu-Xin Li Yang Liu Ming-Gui Chen Li-Xia Xiong Na Yang Zheng-Ming Li 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University,Tianjin 300071, China

出　　处：《Chinese Chemical Letters》2017年第6期1248-1251,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21372133);973 Program(No.2010CB126106);"111" Project of Ministry of Education of China(No.B06005)

摘　　要：In order to search for novel potent and environmentally benign insecticides,a series of anthranilic diamides containing various fluorinated groups were designed and synthesized.Their structures were confirmed by -1H NMR,-（13）C NMR,-（19）F NMR,elemental analysis,HRMS or mass spectra.Their insecticidal activities against oriental armyworm（Mythimna separata） and diamondback moth（Plutella xyiostella）were evaluated.The preliminary structure-activity relationship（SAR） was discussed in detail.The biological assay indicated that most of the compounds exhibited moderate to excellent insecticidal activities.Especially,Ia showed high larvicidal activity against oriental armyworm.Meanwhile,Iu had better larvicidal effects against diamondback moth than commercial chlorantraniliprole.In order to search for novel potent and environmentally benign insecticides,a series of anthranilic diamides containing various fluorinated groups were designed and synthesized.Their structures were confirmed by -1H NMR,-（13）C NMR,-（19）F NMR,elemental analysis,HRMS or mass spectra.Their insecticidal activities against oriental armyworm（Mythimna separata） and diamondback moth（Plutella xyiostella）were evaluated.The preliminary structure-activity relationship（SAR） was discussed in detail.The biological assay indicated that most of the compounds exhibited moderate to excellent insecticidal activities.Especially,Ia showed high larvicidal activity against oriental armyworm.Meanwhile,Iu had better larvicidal effects against diamondback moth than commercial chlorantraniliprole.

关 键 词：Anthranilic diamides Fluorinated moieties Insecticidal activities Structure-activity relationship Synthesis 

分 类 号：TQ453[化学工程—农药化工]