云南白族育龄妇女雌激素-β受体基因多态性研究  

Study on estrogen receptor-β gene polymorphism among Bai women of childbearing age in Yunnan province

作　　者：王建兰 袁彦玲 郑水 张雪鹏 赵春玉 

机构地区：[1]云南省人口和计划生育科学技术研究所生殖医学治疗中心,云南昆明650021 [2]大理白族自治州剑川县妇幼保健计划生育服务中心,云南剑川671300

出　　处：《中国妇幼保健》2017年第13期2971-2973,共3页Maternal and Child Health Care of China

摘　　要：目的研究云南白族育龄妇女人群雌激素-β(ER-β)受体基因多态性的分布特征及与其他种族的差异。方法以196例云南白族育龄妇女人群为研究对象,分析其ER-β基因rs1256049(RsaⅠ)和rs4986938(AluⅠ)位点的基因型频率和等位基因频率的分布特征,同时与其他的人群结果进行比较。结果 RsaⅠ位点基因型为AA的有20例(10.2%)、为AG的有106例(54.1%)、为GG的有70例(35.7%),AluⅠ位点基因型为AA的有1例(0.5%)、为AG的有67例(34.2%)、为GG的有128例(65.3%)。结论云南白族育龄妇女人群RsaⅠ和AluⅠ位点多态性的分布与其他种族存在一定差异。Objective To research the distribution characteristics of estrogen receptor-β gene polymorphism among Bai women of childbearing age in Yunnan province and the differences compared with other ethnic groups.Methods A total of 196 Bai women of childbearing age in Yunnan province were selected as study object.The distribution characteristics of frequencies of genotypes and alleles in ER-β gene rs1256049（Rsa Ⅰ） and rs4986938（Alu Ⅰ） sites were analyzed,then the results were compared with other ethnic groups.Results The distribution frequencies of RsaⅠ site AA,AG,and GG genotypes were 10.2%（20 women）,54.1%（106 women）,and35.7%（70 women）,respectively.The distribution frequencies of Alu Ⅰ site AA,AG,and GG genotypes were 0.5%（one woman）,34.2%（67 women）,and 65.3%（128 women）.Conclusion The distributions of Rsa Ⅰ and Alu Ⅰ sites polymorphisms among Bai women of childbearing age in Yunnan province are different from other ethnic groups.

关 键 词：云南白族育龄妇女 雌激素受体-Β 基因多态性 

分 类 号：R173[医药卫生—妇幼卫生保健]