丹参川芎嗪联合长春西汀治疗颅脑损伤后遗症的临床研究  

Clinical Study of Danshen Chuanxiongqin Injection Combined with Vinpocetine in Treatment of Sequelae after Craniocerebral Injury

作　　者：徐春林[1] 熊学辉[1] 吴雅兰[1] 方丽萍[1] 魏小川[1] 

机构地区：[1]黄冈市中心医院神经外科,湖北黄冈438000

出　　处：《湖南中医药大学学报》2017年第8期910-912,共3页Journal of Hunan University of Chinese Medicine

基　　金：黄冈市科技计划项目医药院校一般项目(WJ2016Y-000)

摘　　要：目的探讨丹参川芎嗪联合长春西汀治疗脑损伤后遗症的临床疗效。方法选择我院收治的颅脑损伤后遗症患者80例为研究对象,随机分为两组,每组40例,对照组患者予能量合剂+高压氧治疗,观察组予丹参川芎嗪注射液+长春西汀注射液治疗,观察两组患者临床疗效及治疗后血液流变学指标的变化。结果观察组患者治疗总有效率为92.5%,明显高于对照组的75.0%,差异有统计学意义(P<0.05);观察组患者治疗后全血比粘度(高切、中切、低切)、血浆粘度、红细胞压积、纤维蛋白原以及血清hs-CRP均较治疗前明显降低,且明显低于对照组水平,差异有统计学意义(P<0.05);对照组治疗后上述指标与治疗前比较均无统计学差异(P>0.05)。结论丹参川芎嗪联合长春西汀治疗脑损伤后遗症可有效减轻炎症反应,改善患者的血液高粘滞状态,进而增加脑血流量,提高临床疗效。Objective To investigate the clinical effect of Danshen Chuanxiongjin injection combined with vinpocetine in treatment of sequelae after craniocerebral injury. Methods 80 cases of patients with sequelae after craniocerebral injury treated in our hospital as the research object, they were randomly divided into two groups, 40 cases in each group. The control group was treated with energy mixture ＋ hyperbaric oxygen therapy, the observation group received Danshen Chuanxiongqin injection＋ vinpocetine Injection treatment. The clinical curative effect and blood rheology index after treatment were observed. Results The total efficiency in the observation group （92.5%） was significantly higher than the control group （75.0%）, the difference was statistically significant （P〈0.05）. The whole blood viscosity （high-cut, medium and low-cut）, plasma viscosity, hematocrit, fibrinogen and serum hs-CRP in the observation group was significantly lower after treatment, and also obviously lower than the the control group （P〈0.05）. The indicators in the control group showed no significant difference after treatment （P〉0.05）. Conclusion Danshen Chuanxiongqin injection combined with vinpocetine could effectively reduce the degree of inflammation in the treatment of sequelae after craniocerebral, improve the high blood viscosity, increase the cerebral blood flow, and then im-prove clinical efficacy.

关 键 词：颅脑损伤 后遗症 丹参川芎嗪 长春西汀 血液流变学 

分 类 号：R651.1[医药卫生—外科学] R285[医药卫生—临床医学]