机构地区:[1]北京协和医学院中国医学科学院国家心血管病中心阜外医院心律失常中心,北京市100037
出 处:《中国循环杂志》2017年第7期665-668,共4页Chinese Circulation Journal
基 金:国家重点基础研究发展规划(G2006CB503805);国家高技术研究发展计划基金(2006AA02Z477)
摘 要:目的:探究合并快静息心率的高血压患者的临床特征及其常见临床合并症情况。方法:本研究回顾性分析了2000年山东青岛港研究和2005年河南信阳研究纳入的静息心电图资料完整的18岁以上社区人群,包括高血压与非高血压患者。收集患者的临床合并症(包括糖尿病、冠心病、高脂血症、脑卒中等)、实验室检查结果、心电图静息心率(RHR)、体重指数(BMI)、腰臀比以及诊室血压。结果:纳入受试者18 183例,61.6%为男性,平均年龄(45.2±12.7)岁,高血压患者6 763例。高血压患者的静息心率明显高于正常血压人群[(73.5±11.6)次/min vs(70.6±9.6)次/min,P<0.001],合并快静息心率的患者比例显著高于非高血压者(14.5%vs 6.4%,P<0.001)。在高血压患者中,与正常静息心率的患者相比,合并快静息心率的患者年龄更大[(51.8±11.2)岁vs(53.9±12.2)岁,P<0.001),体重指数更低([26.4±3.4)kg/m^2 vs(25.8±3.6)kg/m^2,P<0.001],3级高血压患者比例更高(59.0%vs 68.2%,P<0.001),空腹血糖[(5.6±1.5)mmol/L vs(6.0±2.4)mmol/L,P<0.001]、甘油三酯([1.7±1.3)mmol/L vs(2.0±1.8)mmol/L,P<0.001]及低密度脂蛋白胆固醇水平更高([3.1±0.8)mmol/L vs(3.2±0.9)mmol/L,P=0.001)],合并糖尿病(3.9%vs 6.6%,P=0.007)和脑卒中(8.3%vs 11.1%,P=0.005)的比例高。多因素回归分析校正传统危险因素后发现,快静息心率与高血压患者的脑卒中风险呈正相关(OR=1.306,95%CI:1.021~1.671)。结论:高血压人群中快静息心率比例显著高于正常血压人群。合并快静息心率的高血压患者年龄更大,体重指数更低,多为3级高血压患者,且多合并糖尿病、脑卒中。快静息心率增加高血压患者的脑卒中风险。Objective: To explore the clinical features and common complications of fast resting heart rate (RHR) in hypertensionpatients. Methods: We retrospectively analyzed the entire rest electrocardiogram data of Qingdao study 2000 and Xinyang study2005 in community population elder than 18 years including hypertension patients and non-hypertension subjects. Clinical complications as diabetes, coronary artery disease, hyperlipidemia and stroke, laboratory findings, RHR in ECG, body mass index (BMI), waist to hip ratio and office blood pressure were collected in all participants. Results: A total of 18183 participants were enrolled including 61.6% male, the average age was (45.2±12.7) years including 6763 hypertension patients. Compared with normal BP subjects, hypertension patients had the faster RHR (73.5±11.6) times/min vs (70.6±9.6) times/min, P〈0.001 and more hypertension patients combining fast RHR (14.5% vs 6.4%), P〈0.001. In hypertension patients, compared with normal RHR patients, fast RHR patients had the elder age (53.9±12.2) years vs (51.8±11.2) years, lower BMI (25.8±3.6) kg/m^2 vs (26.4±3.4) kg/m^2 and higher ratio of grade 3 hypertension (68.2% vs 59.0%), all P〈0.001; higher levels of fasting blood glucose (6.0±2.4) mmol/L vs (5.6±1.5) mmol/L and triglyceride (2.0±1.8) mmol/L vs (1.7±1.3) mmol/L, both P〈0.001, higher LDL-C (3.2±0.9) mmol/L vs (3.1±0.8) mmol/L, P=-0.001; more patients with diabetes (6.6% vs 3.9%), P=-0.007 and stroke (11.1% vs 8.3%), P=0.005. Multivariate regression analysisindicated that with adjusted traditional risk factors, fast RHR was positively related to stroke occurrence in hypertension patients (OR=1.306, 95% CI 1.021-1.671). Conclusion: Fast RHR happened more in hypertension patients than in normal BP subjects; it had the increased risk for stroke occurrence in hypertension patients.
分 类 号:R54[医药卫生—心血管疾病]
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