Intercalated 2D nanoclay for emerging drug delivery in cancer therapy  

作　　者：Yi Zhang Mei Long Peng Huang Huaming Yang Shi Chang Yuehua Hu Aidong Tang Linfeng Mao 

机构地区：[1]Department of Inorganic Materials, School of Minerals Processing and Bioengineering, Central South University, Changsha 410083, China [2]Xiangya Hospital, Central South University, Changsha 410078, China [3]Hunan Key Laboratory of Mineral Materials and Application, Central South University, Changsha 410083, China [4]School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China

出　　处：《Nano Research》2017年第8期2633-2643,共11页纳米研究（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China （Nos. 51225403 and 41572036）, the Hunan Provincial Science and Technology Project （Nos. 2016RS2004 and 2015TP1006）, the Postdoctoral Science Foundation of Central South University （No. 155219） and the China Postdoctoral Science Foundation （No. 2015M582346）.

摘　　要：Natural two-dimensional （2D） kaolinite nanoclay has been incorporated into an emerging drug delivery system. The basal spacing of the kaolinite nanoclay was expanded from 0.72 to 4.16 nm through the intercalation of various organic guest species of different chain lengths, which can increase the efficiency in drug delivery and reduce the toxicity of doxorubicin （DOX）. Original kaolinite （Kaolin） and the Kaolin intercalation compounds exhibited a high level of biocompatibility and very low toxicity towards cells of pancreatic cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer, esophageal cancer, and differentiated thyroid cancer. However, lung cancer and hepatocellular cancer cells need more strict compositional, structural, and morphological modulations for drug delivery carriers. DOX-Kaolin and the DOX-Kaolin intercalation compounds showed dramatically faster drug release in moderately acidic solution than in neutral condition, and exhibited enhanced therapeutic effects against ten model cancer cell cultures in a dose-dependent manner. The use of 2D nanoclay materials for a novel drug delivery system could feasibly pave a way towards high-performance nanotherapeutics, with superior antitumor efficacy and significantly reduced side effects.Natural two-dimensional （2D） kaolinite nanoclay has been incorporated into an emerging drug delivery system. The basal spacing of the kaolinite nanoclay was expanded from 0.72 to 4.16 nm through the intercalation of various organic guest species of different chain lengths, which can increase the efficiency in drug delivery and reduce the toxicity of doxorubicin （DOX）. Original kaolinite （Kaolin） and the Kaolin intercalation compounds exhibited a high level of biocompatibility and very low toxicity towards cells of pancreatic cancer, gastric cancer, prostate cancer, breast cancer, colorectal cancer, esophageal cancer, and differentiated thyroid cancer. However, lung cancer and hepatocellular cancer cells need more strict compositional, structural, and morphological modulations for drug delivery carriers. DOX-Kaolin and the DOX-Kaolin intercalation compounds showed dramatically faster drug release in moderately acidic solution than in neutral condition, and exhibited enhanced therapeutic effects against ten model cancer cell cultures in a dose-dependent manner. The use of 2D nanoclay materials for a novel drug delivery system could feasibly pave a way towards high-performance nanotherapeutics, with superior antitumor efficacy and significantly reduced side effects.

关 键 词：cancer therapy NANOCLAY INTERCALATION drug delivery BIOCOMPATIBILITY 

分 类 号：TQ460.4[化学工程—制药化工] O613.71[理学—无机化学]