心肌肥厚重塑的免疫机制研究进展  

Progress of reseaches on the immunological mechanisms in cardiac hypertrophy and remodeling

作　　者：门素珍 董浩[1] 孙孟华 刘巍[1] 

机构地区：[1]哈尔滨医科大学附属第一医院内科危重症科,150001

出　　处：《国际免疫学杂志》2017年第3期317-320,共4页International Journal of Immunology

基　　金：国家自然科学基金（81270310）;哈尔滨市科技创新人才研究专项资金（杰出青年人才）（2016RAYBJ005）;黑龙江省教育厅海外学人重点项目（1252HQ013）

摘　　要：心血管疾病严重威胁人类健康,其继发的心肌肥厚和重塑是导致心脏功能逐渐恶化的关键因素.近年来,分子免疫学机制在心肌肥厚和重塑形成中的作用逐渐引起关注.研究多种细胞类型在心肌肥厚和重塑中的作用,如非心肌细胞,尤其是免疫细胞相互作用和炎症信号作用的机制,巨噬细胞、成纤维细胞和肾素-血管紧张素-醛固酮系统在心肌肥厚与重塑病理生理中的作用,对不同免疫细胞类型在心肌细胞肥大调控具有重要性以及潜在的治疗靶点.Cardiovascular diseases are a serious detriment to human health,and the secondary cardiac hypertrophy and remodeling are a key factor for worsen cardiac function.Recently,the formation of cardiac hypertrophy and remodeling have been indicted to correlate with molecular immune system.This review summarizes the vital role of the variety of cell types,such as the non-myocardial cells,in the pathogenesis of cardiac hypertrophy and remodeling.We give special attention to the interaction between immune cells and the role of inflammatory signaling.The role of macrophages,fibroblasts,and renin-angiotensin-aldosterone system in the pathophysiology of myocardial hypertrophy and remodeling,was described.We also discussed the potential therapeutic targets of this disorder.

关 键 词：巨噬细胞 趋化因子 Kruppel样因子-5 心脏重塑 

分 类 号：R54[医药卫生—心血管疾病]