吸烟与冠心病合并高血压患者血同型半胱氨酸及白细胞水平之间的关系  

The Correlation Analysis Between Smoking with Serum Homocysteinelevel and White Blood Cell in Patients with Coronary Artery Disease and Hypertension

作　　者：王嘉慧[1] 韩秀[1] WANG J ia-hui HAN Xiu(Department of Cardiovascular Examination, the First Affiliated Hospital of Dalian Medical University ,Dalian 116011, China)

机构地区：[1]大连医科大学附属第一医院心血管检查科,辽宁大连116011

出　　处：《医学与哲学（B）》2017年第4期37-40,共4页Medicine & Philosophy(B)

摘　　要：探讨分析吸烟与高血压病(HTN)合并冠心病(CAD)患者血同型半胱氨酸(Hcy)及白细胞(WBC)计数水平之间的关系。选择CAD合并HTN患者148例,HTN患者179例,测定血Hcy、WBC、血脂水平等指标,分析CAD+HTN组与HTN组病例间不同吸烟状况对血Hcy、WBC、血脂水平的影响。在各项检查指标中,同型半胱氨酸(Hcy)、总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白(LDL-C)在两组之间有显著性差异(P<0.05)。吸烟使高血压患者血Hcy、WBC、血脂水平升高,这也可能是吸烟促进HTN患者CAD发生发展的关键机制,可作为HTN患者CAD发展程度的判定指标,为早期诊断、预防和控制HTN合并CAD的发生和发展提供参考。The objective of this study is to investigate the correlation between smoking and serum homocysteine （Hcy） level as well as white blood cell （WBC） in patients with coronary artery disease and hypertension. In this study, Hcy, WBC and blood lipid were obtained from 148 patients with coronary artery disease and hypertension and 179 patients with hypertension. The impacts of smoking on Hcy, WBC and blood lipid were analyzed respectively. In these indicators, significant differences in Hcy, total cholesterol （TC）, triglyceride （TG） and low density lipoprotein （LDL-C） were found between the two groups （P〈0.05）. Smoking may increase the Hcy, WBC and blood lipid levels. This may be the key mechanism of smoking promoting the development of CAD with HTN. Smoking can be used as indicators of development degree of CAD patients, which may be helpful for the early diagnosis, prevention and treatment.

关 键 词：冠状动脉硬化型心脏病 高血压病 同型半胱氨酸 白细胞 

分 类 号：R541.4[医药卫生—心血管疾病]