造血干细胞老化与mTOR信号通路  

Senescence of Hematopoietic Stem Cells and mTOR Signaling Pathway

作　　者：曾慧红[1] 朱清仙[1] 匡渤海[2] 范广勤[3] 邵立健[3] Zeng Huihong Zhu Qingxian Kuang Bohai Fan Guangqin Shao Lijian(tDepartment of Histology and Embryology, Basic Medical College, Nanchang University, Nanchang 330006, Chin Department of Medical Genetics and Cell Biology, Basic Medical College, Nanchang University, Nanchang 330006, China School of Public Health, Nanchang University, Nanchang 330006, China)

机构地区：[1]南昌大学基础医学院组织胚胎学教研室,南昌330006 [2]南昌大学基础医学院医学遗传与细胞生物学教研室,南昌330006 [3]南昌大学公共卫生学院,南昌330006

出　　处：《中国细胞生物学学报》2017年第6期811-818,共8页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81160050;30900574;81460110);江西省教育厅科技计划(批准号:GJJ14102);江西省研究生创新专项资金(批准号:YC2016-B028)资助的课题~~

摘　　要：衰老是一个生命的自然过程,也是世界性的健康问题,目前并无有效延缓衰老的对策。细胞老化可能在哺乳动物衰老发生、发展方面起关键作用,特别是成人干细胞的老化现象。该综述主要回顾了生理和病理环境条件下造血干细胞老化的证据。近年来,随着研究的深入,对细胞老化的理解及其机制有了新的认识,不仅包括传统的p53/p21途径和p16/Rb途径,而且G-CSF/STAT3/BATF通路和衰老相关分泌表型(senescence-associated secretory phenotype,SASP)也引起学者们的重视。有效清除体外和体内老化细胞已经成为可能。最近有研究表明,mTOR(mammalian target of rapamycin)信号通路激活后参与细胞老化的发生、发展过程。在细胞老化机制深入研究基础上,这为进一步探索预防老化细胞产生或有效消除老化细胞的方法提供了新思路。Aging is a process in life but becomes a worldwide health issue with unresolved strategies to extend lifespan. Recent studies have shown that cellular senescence might play crucial roles in mammalian aging, specifically in adult stem cell senescence. We presently reviewed the evidence of hematopoietic stem cell senescence in physiological and pathological contexts. Understanding mechanisms of senescence have been made significant improvement including p53/p21 pathway, p16/Rb pathway, G-CSF/STAT3/BATF pathway and SASP. Depletion of senescent cells has become possible in vitro and in vivo. Activation of m TOR signaling pathway may be involved in the initiation and development of cellular senescence. These remarkable findings will provide us new opportunities for developing the mechanism-based strategies to prevent and/or deplete senescent cells in near future.

关 键 词：造血干细胞 衰老 细胞老化 MTOR信号通路 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]