脂肪细胞分化的分子机制研究进展  

Advance in Molecular Mechanism of Adipocyte Differentiation

作　　者：伍家利 张秀玲[1] 杜润家[2] 黄睿[1] 赵志芳[1] 杨战利[1] Wu Jiali Zhang Xiuling Du Runjia Huang Rui Zhao Zhifang Yang Zhanli(Medical College of Northwest Minzu University, Lanzhou 730030, China Department of Ultrasound, Gansu Provincial Cancer Hospital, Lanzhou 730050, China)

机构地区：[1]西北民族大学医学院,兰州730030 [2]甘肃省肿瘤医院超声科,兰州730050

出　　处：《中国细胞生物学学报》2017年第6期826-832,共7页Chinese Journal of Cell Biology

基　　金：中央高校基本科研业务费专项资金项目(批准号:31920160069;31920150041)资助的课题~~

摘　　要：肥胖已经成了世界性的健康问题,肥胖是由于个体的吸收大于消耗而引起的,在细胞水平上,肥胖是由于脂肪细胞的数目增多或单个脂肪细胞体积增大引起的。脂肪的形成被分为两个阶段:第一阶段,新的脂肪细胞从间充质干细胞产生或者原有脂肪细胞通过去分化形成前脂肪细胞;第二阶段,前脂肪细胞通过终末分化形成成熟的脂肪细胞。脂肪的分化过程在前脂肪细胞系3T3-L1中被广泛的研究。该文综述了前脂肪细胞分化的调控机制,其中,主要涉及前脂肪细胞向终末分化细胞转化过程中的脂肪细胞关键基因表达调控因子过氧化物体增殖物受体γ(peroxisome proliferator-activated receptorγ,PPARγ)的表观遗传修饰及活化的PPARγ与CCAAT增强子结合蛋白家族(CCAAT/enhancer-binding protein,C/EBP)转录因子的协同作用,同时,也讨论了目前对脂肪分化作用方面的研究热点。Obesity is an increasing health problem all over the world. Obesity occurs when energy intake by an individual exceeds the rate of energy expenditure. At the cellular level, obesity was originally considered a hypertrophic disease resulting from an increase in the number and/or the size of individual adipocytes. Adipogenesis is thought to occur in two stages. In the first stage, new fat cells could arise from a mesenchymal stem cells or through the dedifferentiation of adipocytes to preadipocytes. Then preadipocytes proliferate and terminal differentiation into mature adipocytes in the second stage. The differentiation of adipocytes from preadipocytes has been extensively studied in the cell lines of preadipocyte such as 3T3-L1. This paper reviewed the advance in molecular mechanism of differentiation of adipocytes which mainly involved the epigenomic activation of peroxisome proliferator-activated receptor γ（PPARγ） induced by adipogenic stimuli and the synergistic action between activated PPARγ and CCAAT enhancer binding protein（C/EBP） family transcription factors during the process of transformation from committed preadipocytes to terminally differentiated cells. Meanwhile, the focal points and developing trend about the differentiation of adipocytes were also discussed.

关 键 词：脂肪生成 脂肪细胞分化 过氧化物体增殖物受体 CCAAT增强子结合蛋白 3T3-L1细胞 

分 类 号：R589.2[医药卫生—内分泌]